FB2021_02, released April 13, 2021

Gene: Dmel\CG13397

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General Information
Symbol
Dmel\CG13397
Species
D. melanogaster
Name
Annotation Symbol
CG13397
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014417
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ESTS:172F5T

Key Links
Genomic Location
Cytogenetic map
29C3-29C3
Sequence location
2L:8,408,888..8,411,868 [-]
Recombination map
2-32
RefSeq locus
NT_033779 REGION:8408888..8411868
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (1 term)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables alpha-N-acetylglucosaminidase activity
inferred from sequence or structural similarity
(Louis et al., 1997)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER O-GLYCOSYL HYDROLASES -
Other O-glycosyl hydrolases group is a collection of O-glycosyl hydrolases that do not fit into any of the other major O-glycosyl hydrolase groups.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG13397 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG13397-RA
FBtr0079711
NM_143788
2741
778
CG13397-RB
FBtr0331991
NM_001273322
2642
778
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG13397-PA
FBpp0079316
89.7
778
8.19
NP_652045
AAF52672
CG13397-PB
FBpp0304313
89.7
778
8.19
NP_001260251
AGB92787
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

778 aa isoforms: CG13397-PA, CG13397-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG13397 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body

Comment: cyclical, peak ZT13-16

(Xu et al., 2011)
Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG13397 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG13397
Transgenic constructs containing regulatory region of CG13397
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel8021
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NAGLU
15 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Naglu
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Naglu
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\naglu
3 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\naglu
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\K09E4.4
11 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\CYL1
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904HJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000355
Drosophila simulans
Dsim\GD22403
Drosophila sechellia
Dsec\GM12949
Drosophila erecta
Dere\GG23441
Drosophila yakuba
Dyak\GE10991
Drosophila ananassae
Dana\GF14678
Drosophila pseudoobscura pseudoobscura
Dpse\GA12255
Drosophila persimilis
Dper\GL25802
Drosophila willistoni
Dwil\GK28294
Drosophila willistoni
Dwil\GK18384
Drosophila virilis
Dvir\GJ18000
Drosophila mojavensis
Dmoj\GI17241
Drosophila grimshawi
Dgri\GH13491
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502FI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17026202
Glossina morsitans
Tsetse fly
Gmor\GMOY008256
Mayetiola destructor
Hessian fly
Mdes\Mdes006592
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003150
Anopheles darlingi
American malaria mosquito
Adar\ADAC008321
Anopheles gambiae
Malaria mosquito
Agam\AGAP011750
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015627
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02NG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009235
Danaus plexippus
Monarch butterfly
Dple\DPOGS213790-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL013911
Apis florea
Little honeybee
Aflo\2858492948
Apis mellifera
Western honey bee
Amel\GB42551
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23654
Bombus terrestris
Buff-tailed bumblebee
Bter\15205820
Linepithema humile
Argentine ant
Lhum\LH16063
Linepithema humile
Argentine ant
Lhum\LH16065
Linepithema humile
Argentine ant
Lhum\LH16067
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002f2d
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005152
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12559
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07912
Pediculus humanus
Human body louse
Phum\PHUM256940
Rhodnius prolixus
Kissing bug
Rpro\RPRC014312
Cimex lectularius
Bed bug
Clec\CLEC000461
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10539
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02KN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012636
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79408.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79407.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_35389
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301977
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02QN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Naglu_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Naglu_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Naglu
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022316
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024553
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002106
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NAGLU; N-acetyl-alpha-glucosaminidase
15 of 15
609701
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-32
Cytogenetic map
29C3-29C3
Sequence location
2L:8,408,888..8,411,868 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
29C3-29C3
Limits computationally determined from genome sequence between P{lacW}l(2)k12914k12914&P{lacW}Akap200k07118a and P{lacW}l(2)k03706k03706&P{lacW}Acerk07704
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
29A-29A
(determined by in situ hybridisation)
(Louis et al., 1997, EDGP Project Members, 1994-)
Cytological site tentative; in situ of cosmid 172F5 also hybridized to 25A.
(EDGP Project Members, 1994-)
Experimentally Determined Recombination Data
Location

2-32

(FlyBase, 2016)

2-27.9

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (8)
Genomic Clones (16)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: ESTS:172F5T CG13397

    (FlyBase, 1996-)
    Additional comments

    Source for merge of ESTS:172F5T CG13397 was sequence comparison ( date:010108 ).

    (FlyBase, 1996-)
    Other Comments

    The existence of this gene is tentative, and is based on a match of an STS sequence from a European Drosophila Genome Mapping Project cosmid.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 44 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (4)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (39)