FB2026_03 , released September 17, 2026
Complex: TRANSCRIPTION FACTOR II H HOLOENZYME COMPLEX
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General Information
Name
TRANSCRIPTION FACTOR II H HOLOENZYME COMPLEX
Species
D. melanogaster
Symbol
TFIIH
FlyBase ID
FBgg0000350
Date last reviewed
2026-04-13
Number of members
10
Description
Description
The general transcription factor complex Transcription factor II H (TFIIH) is required in RNA pol II transcription at initiation, promoter escape, early elongation steps and transcription re-initiation after polymerase pausing. TFIIH can be divided into two subcomplexes: core and cyclin-dependent protein kinase-activating kinase (CAK). Only the TFIIH holoenzyme is transcription-competent. (Adapted from PMID:25693126, PMID:20419276, PMID:21592869).
Notes on Group
Source Material
The TRANSCRIPTION FACTOR II H HOLOENZYME COMPLEX Gene Group has been compiled using the following publication(s): Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Larochelle et al., 2001, and Aoyagi and Wassarman, 2000 .
Key Gene Ontology (GO) terms
Molecular Function
RNA polymerase II general transcription initiation factor activity
Biological Process
transcription initiation at RNA polymerase II promoter
Cellular Component
transcription factor TFIIH holo complex
Related Gene Groups
Parent group(s)
GENERAL TRANSCRIPTION FACTOR COMPLEXES
Component group(s)
CDK-ACTIVATING KINASE COMPLEX
TRANSCRIPTION FACTOR II H - CORE COMPLEX
Members (10)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
TFIIH
General transcription factor TFIIH complex
TFIIH holoenzyme
TF-IIH
TRANSCRIPTION FACTOR II H
TRANSCRIPTION FACTOR II H HOLOENZYME
TRANSCRIPTION FACTOR II H HOLOENZYME COMPLEX
Secondary FlyBase ID(s)
References (6)