Complex: CDK-ACTIVATING KINASE COMPLEX

General Information

Name

CDK-ACTIVATING KINASE COMPLEX

Species

D. melanogaster

Symbol

CAK

FlyBase ID

FBgg0000356

Date last reviewed

Number of members

Description

The cyclin-dependent kinase (CDK)-activating kinase (CAK) complex is a three-subunit kinase module present as a subcomplex of TFIIH, as free trimeric CAK or in complex with the ATP-dependent DNA helicase XPD (Xpd in D.mel). The TFIIH-associated CAK complex phosphorylates the C-terminal domain of RNA pol II. The free form of CAK activates the cell cycle CDKs. The CAK-XPD complex regulates the cell cycle progression in mitosis. (Adapted from FBrf0227236 and PMID:21592869).

Notes on Group

Source Material

The CDK-ACTIVATING KINASE COMPLEX Gene Group has been compiled using the following publication(s): Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Larochelle et al., 2001, and Aoyagi and Wassarman, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

RNA polymerase II CTD heptapeptide repeat kinase activity

cyclin-dependent protein serine/threonine kinase activity

Biological Process

transcription initiation at RNA polymerase II promoter

regulation of cyclin-dependent protein serine/threonine kinase activity

Cellular Component

carboxy-terminal domain protein kinase complex

transcription factor TFIIH holo complex

Enzymatic activity

Enzyme name (EC)