Gene Group: UBIQUITIN TRANSFERASES

General Information

Name

UBIQUITIN TRANSFERASES

Species

D. melanogaster

Symbol

UBT

FlyBase ID

FBgg0001218

Date last reviewed

2019-07-25

Number of members

181

Description

Ubiquitin transferases catalyse the transfer of ubiquitin from one protein to another. They include ubiquitin-conjugating (E2) enzymes and ubiquitin ligase (E3) enzymes, which act sequentially to result in covalent attachment of ubiquitin to target proteins. Ubiquitination is required for many cellular processes, including protein degradation by the proteasome, cell cycle progression, transcriptional regulation, DNA repair and signal transduction. (Adapted from PMID:27015313.)

Notes on Group

Source Material

The UBIQUITIN TRANSFERASES Gene Group has been compiled using the following publication(s): Washington et al., 2020, Zavortink et al., 2020, Ji et al., 2014, Wisotzkey et al., 2014, Yamazaki et al., 2013, Darding and Meier, 2012, Vandenabeele and Bertrand, 2012, Du et al., 2011, Ying et al., 2011, Marin, 2010, Marin, 2010, Michelle et al., 2009, Rotin and Kumar, 2009, Rotin and Kumar, 2009, Sardiello et al., 2008, Eisenhaber et al., 2007, Jin and Harper, 2002, Jones et al., 2002, and Pham and Sauer, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

ubiquitin-protein transferase activity

Biological Process

protein ubiquitination

Cellular Component

Related Gene Groups

Parent group(s)

UBIQUITIN-LIKE PROTEIN TRANSFERASES

Component group(s)

E2 UBIQUITIN CONJUGATING ENZYMES

E3 UBIQUITIN LIGASES