Gene Group: PSEUDOENZYMES

General Information

Name

PSEUDOENZYMES

Species

D. melanogaster

Symbol

PSENZ

FlyBase ID

FBgg0001798

Date last reviewed

2022-10-27

Number of members

319

Description

Pseudoenzymes are proteins that are evolutionary related to enzymes but lack relevant catalytic activity. Despite this, many pseudoenzymes are remarkably well conserved and have evolved essential catalytic-independent functions. They are found in almost all enzyme families and are distributed across the whole tree of life. The most abundant pseudoenzyme groups are pseudokinases, pseudophosphatases and pseudoproteases. (Adapted from PMID:31733177 and PMID:31618524.)

Notes on Group

Source Material

The PSEUDOENZYMES Gene Group has been compiled using the following publication(s): Attrill, 2026.1.22, Ishikawa et al., 2025, Zaru and Marygold, 2025, Rabadiya and Behr, 2024, Werner et al., 2024, Heidarian et al., 2023, Shekhar et al., 2023, Sustar et al., 2023, Erven et al., 2022, Li et al., 2022, Shippy et al., 2022, Holleufer et al., 2021, Meyer et al., 2021, Behr and Riedel, 2020, Pandey et al., 2020, Elías-Villalobos et al., 2019, Jiang, 2019.3.1, Laurinyecz et al., 2019, Mele and Johnson, 2019, Metwally et al., 2019, Naba et al., 2019.7.9, Cao and Jiang, 2018, Meyer et al., 2018.7.18, Zimmerman et al., 2017, Chen et al., 2016, Lazzaretti et al., 2016, Parkhitko et al., 2016, Pesch et al., 2016, Cenci et al., 2015, Hatzihristidis et al., 2015, Kollmar, 2015.9.15, Reynaud et al., 2015, Kurata, 2014, Sitnik et al., 2014, Sopko et al., 2014, Clague et al., 2013, Crosby et al., 2013.1.30, Fan et al., 2013, Lombard et al., 2013, Masoner et al., 2013, Okamoto et al., 2013, Petrova et al., 2013, Vogel et al., 2013, Adolphsen et al., 2012, Chen et al., 2012, Rincon-Arano et al., 2012, Rogers and Hartl, 2012, Saisawang et al., 2012, Dorus et al., 2011, Du et al., 2011, Fenckova et al., 2011, Kraft et al., 2011, Yuan et al., 2011, Zhang et al., 2011, Cooper et al., 2010, Anamika et al., 2009, Belote and Zhong, 2009, Biswas et al., 2009, Horne et al., 2009, Liu et al., 2009, Michelle et al., 2009, Odronitz et al., 2009, Takeda et al., 2009, Bland et al., 2008, Burtenshaw et al., 2008, Dixit et al., 2008, Zhu et al., 2008, Funkhouser and Aronson, 2007, Klose et al., 2006, Martinez Agosto and McCabe, 2006, Rendic et al., 2006, Tian and Ten Hagen, 2006, Chihara et al., 2005, Landis and Tower, 2005, Friedrich et al., 2004, Wagner et al., 2004, Zhu et al., 2004, Kocks et al., 2003, Mellroth et al., 2003, Gakh et al., 2002, Hayashi et al., 2002, Ma et al., 2002, Manning et al., 2002, Tzolovsky et al., 2002, Urban et al., 2002, Zurovec et al., 2002, Berg et al., 2001, Halford and Stacker, 2001, Tijet et al., 2001, Coates et al., 2000, Fenwick et al., 2000, Guichard et al., 2000, Kim et al., 2000, Ohlstein et al., 2000, Sheffield et al., 2000, Wasserman et al., 2000, Yamashita et al., 2000, Okano et al., 1999, Persson et al., 1997, Rawlings and Barrett, 1996-, and Jeffs et al., 1994 .

Key Gene Ontology (GO) terms

Molecular Function

Biological Process

Cellular Component

Related Gene Groups

Component group(s)

IMAGINAL DISC GROWTH FACTORS

NON-MOTOR MYOSINS

NON-PEPTIDASE HOMOLOGS

PSEUDO-CHITINASES

PSEUDO-CHITIN DEACETYLASES

PSEUDOKINASES