Complex: RNA EXOSOME COMPLEXES

General Information

Name

RNA EXOSOME COMPLEXES

Species

D. melanogaster

Symbol

RNAEXO

FlyBase ID

FBgg0001939

Date last reviewed

2026-04-27

Number of members

Description

The RNA exosome is a 3'-5' exonuclease complex present in the nucleus and cytoplasm that can process and degrade many types of RNAs, including mRNA, rRNA, snRNA, snoRNA and tRNA. In yeast and humans, the exosome has a barrel structure, the core of which is formed by a ring of six RNase PH domain subunits and a cap of three S1/KH-domain subunits. (Adapted from FBrf0210381 and PMID:27345150).

Notes on Group

Drosophila exosome complexes appear to differ from other eukaryotes as they lack an ortholog to the Rrp43 RNase PH domain subunit (FBrf0210381).

Rrp47 has not been included in the RNA EXOSOME COMPLEXES (RNA-EXO) gene group, as it is considered to be a cofactor (FBrf0210381). CG17982 has not been included, but has been reported to co-purify with this complex under certain experimental conditions (FBrf0155992).

Source Material

The RNA EXOSOME COMPLEXES Gene Group has been compiled using the following publication(s): Lee et al., 2025, Molleston et al., 2016, Kiss and Andrulis, 2010, Graham et al., 2006, Forler et al., 2003, and Andrulis et al., 2002 .

Key Gene Ontology (GO) terms

Molecular Function

3'-5' exonuclease activity

Biological Process

RNA processing

Cellular Component

exosome (RNase complex)

Related Gene Groups

Component group(s)

CYTOPLASMIC EXOSOME COMPLEX

NUCLEAR EXOSOME COMPLEX

Members (10)