FlyBase Gene Report: Dmel\term

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Term: Terminus

Blastoderm-specific locus whose function may involve binding to the DNA (see molecular biology section). In the syncytial blastoderm stage, Term RNA is distributed uniformly throughout the embryo. In late cellular blastoderm, it is concentrated at the posterior pole. At gastrulation, the RNA is found in the invagination that gives rise to the posterior midgut and proctodeum, the region that will form the ventral furrow, and the anterodorsal neurogenic region, but it disappears by the end of the period of germ band extension.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\term for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P11455)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transposon inserted in intron

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

term-RA

FBtr0075112

NM_080143

1469

428

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

term-PA

FBpp0074878

49.2

428

6.32

P11455

NP_524882

AAF49257

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Zinc finger C2H2-type

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\term using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

term_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.19

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

foregut anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

inclusive hindgut primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\term in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\term

View exonic expression by tissue for Dmel\term

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003683

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47208/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003683

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003683

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003683

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4216

Flygut - An atlas of the Drosophila adult midgut

FBgn0003683

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\term

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of term

Transgenic constructs containing regulatory region of term

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)Exel6134

(Ryder, 2004.4.26)

Df(3L)W10

(Baldarelli et al., 1988)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

decreased cell number | blastoderm stage, with Scer\GAL4^{VP16.mat.αTub67C}

Phenotype manifest in

Allele

embryo | blastoderm stage, with Scer\GAL4^{VP16.mat.αTub67C}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:term. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

CG6885

3 of 13

CG7271

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

term - Deaf1

two hybrid

(Hu et al., 2017.6.13)

term - Hr78

two hybrid array

(Shokri et al., 2019)

term - Rel

two hybrid array

(Shokri et al., 2019)

term - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

70682

DroID - A comprehensive database of gene and protein interactions.

FBgn0003683

MIST (protein-protein) - An integrated Molecular Interaction Database

47208

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

75D2-75D3

Sequence location

3L:18,592,303..18,593,771 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

75D2-75D3

Limits computationally determined from genome sequence between P{PZ}W⁰⁵⁰¹⁴ and P{lacW}l(3)j14E7^j14E7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

75C-75C

(determined by in situ hybridisation)

(Roark et al., 1985)

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-41.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

94332

y¹ w^*; PBac{term-GFP.FPTB}VK00037

35681

y¹ sc^* v¹ sev²¹; P{TRiP.GLV21046}attP2

42921

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02614}attP40

FlyORF

F003463

M{UAS-term.ORF-CC}ZH-21F

F001685

M{UAS-term.ORF.3xHA.GW}ZH-86Fb

4216R-2

v109195

v341465

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00535}attP40/CyO-GFP

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (33)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE18236

Other clones

DPiM_RE18236

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003683

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003683

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Mapped to cytological location 75C1-75C2 using overlapping deficiencies.

(Baldarelli et al., 1988)

term has been isolated and characterised.

(Baldarelli et al., 1988)

In the syncytial blastoderm stage, term RNA is distributed uniformly throughout the embryo. In late cellular blastoderm, it is concentrated at the posterior pole. At gastrulation, the RNA is found in the invagination that gives rise to the posterior midgut and proctodeum, the region that will form the ventral furrow and the anterodorsal neurogenic region, but it disappears by the end of the period of germ band extension.

Relationship to Other Genes

Source for database merge of

Source for merge of: term CG4216

(Bayraktaroglu, 2000.4.17)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Bsg75C

CG4216

(Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

Term

(Hsiao et al., 2014, Lindsley and Zimm, 1992)

ter

(Baldarelli et al., 1988)

term

(Örkenby et al., 2023, Shokri et al., 2019, Bischof et al., 2018, Hu et al., 2017.6.13, Karaiskos et al., 2017, Dahlberg et al., 2015, Schertel et al., 2015, Hughes et al., 2014, Chen et al., 2013, Saunders et al., 2013, Japanese National Institute of Genetics, 2012.5.21)

Name Synonyms

Terminus

(Lindsley and Zimm, 1992)

terminus

(Dahlberg et al., 2015)

Secondary FlyBase IDs

FBgn0036792

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

47208

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P11455

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P11455

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q541G1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P11455

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003683

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47208/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003683

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003683

FlyMine - An integrated database for Drosophila genomics

FBgn0003683

InterPro - A database of protein families, domains and functional sites

Zinc finger C2H2-type

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4216

MARRVEL_MODEL - MARRVEL (model organism gene)

47208

Linkouts

BioGRID - A database of protein and genetic interactions.

70682

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003683

DroID - A comprehensive database of gene and protein interactions.

FBgn0003683

DRSC - Results frm RNAi screens

FBgn0003683

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

term_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003683

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003683

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4216

Flygut - An atlas of the Drosophila adult midgut

FBgn0003683

MIST (protein-protein) - An integrated Molecular Interaction Database

47208

References (38)

The following external sites may use different assemblies or annotations than FlyBase.

-0.19

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