FlyBase Gene Report: Dmel\mt:ND2

General Information

Symbol

Dmel\mt:ND2

Species

D. melanogaster

Name

mitochondrial NADH-ubiquinone oxidoreductase chain 2

Annotation Symbol

CG34063

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013680

Gene Model Status

Current

Stock Availability

3 publicly available

Enzyme Name (EC)

NADH:ubiquinone reductase (H(+)-translocating) (7.1.1.2)

Gene Summary

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (UniProt, P03896)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

ND2, dND2, NADH dehydrogenase subunit 2, nad2

Key Links

Genomic Location

Cytogenetic map

Sequence location

mitochondrion_genome:240..1,263 [+]

Recombination map

RefSeq locus

NC_024511 REGION:240..1263

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables NADH dehydrogenase (ubiquinone) activity

inferred from electronic annotation with InterPro:IPR003917, InterPro:IPR010933

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001865432

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitochondrial electron transport, NADH to ubiquinone

inferred from electronic annotation with InterPro:IPR003917, InterPro:IPR010933

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001865432

(GO Reference Genome Project, 2011-)

inferred by curator from GO:0045271

(Agip et al., 2023)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of respiratory chain complex I

inferred from direct assay

(Agip et al., 2023)

inferred from mutant phenotype

(Burman et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in mitochondrial inner membrane

inferred by curator from GO:0045271

(Agip et al., 2023)

part_of respiratory chain complex I

inferred from sequence or structural similarity with UniProtKB:P03891

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Rhooms et al., 2020)

inferred from biological aspect of ancestor with PANTHER:PTN001865432

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX I - CORE SUBUNITS

MITOCHONDRIAL COMPLEX I - TESTIS-SPECIFIC VARIANT

MITOCHONDRIAL COMPLEX I

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION

Protein Family (UniProt)

Belongs to the complex I subunit 2 family. (P03896)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

NADH dehydrogenase (ubiquinone) activity

a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out) (7.1.1.2)

RHEA 29091:

Summaries

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX I - CORE SUBUNITS -: Mitochondrial Complex I is the first and largest holoenzyme of the mitochondrial electron transport chain. It oxidizes NADH from the tricarboxylic acid cycle and β oxidation of fatty acids, reduces ubiquinone and transports protons across the inner membrane, contributing to the proton-motive force. It is also involved in the cellular production of reactive oxygen species. Fourteen distinct subunits form the catalytic centers of the enzyme as they are directly involved in transferring electrons from NADH to ubiquinone, or for generation of the membrane potential - they are referred to as the 'core' or 'central' subunits and are conserved from the ancestral enzyme in bacteria to mammals. Seven core subunits are encoded by mtDNA, while the others are encoded the nuclear genome. (Adapted from PMID:23527692 and FBrf0244962.)
MITOCHONDRIAL COMPLEX I - TESTIS-SPECIFIC VARIANT -: Mitochondrial Complex I is the first and largest holoenzyme of the mitochondrial electron transport chain. It oxidizes NADH from the tricarboxylic acid cycle and β oxidation of fatty acids, reduces ubiquinone and transports protons across the inner membrane, contributing to the proton-motive force. It is also involved in the cellular production of reactive oxygen species. Fourteen distinct subunits form the catalytic centers of the enzyme as they are directly involved in transferring electrons from NADH to ubiquinone, or for generation of the membrane potential. (Adapted from PMID:23527692 and FBrf0244962.)
MITOCHONDRIAL COMPLEX I -: Mitochondrial Complex I is the first and largest holoenzyme of the mitochondrial electron transport chain. It oxidizes NADH from the tricarboxylic acid cycle and β oxidation of fatty acids, reduces ubiquinone and transports protons across the inner membrane, contributing to the proton-motive force. It is also involved in the cellular production of reactive oxygen species. Fourteen distinct subunits form the catalytic centers of the enzyme as they are directly involved in transferring electrons from NADH to ubiquinone, or for generation of the membrane potential. (Adapted from PMID:23527692 and FBrf0244962.)

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION -: Oxidative phosphorylation (OXPHOS) is the coordinated transfer of electrons and protons leading to the production of ATP. The OXPHOS system is composed of five mitochondrial inner membrane complexes, Complexes I-IV comprise the electron respiratory chain and Complex V the ATP synthase. Complexes I and II oxidize the electron donors NADH and FADH2, respectively, derived from the tricarboxylic acid (TCA) cycle, and the electrons are transferred to the electron carrier ubiquinone which shuttles them to Complex III. Cytochrome c transfers electrons between Complex III and the terminal complex in the respiratory chain, Complex IV. Complex IV catalyzes electron transfer from reduced cytochrome c to oxygen. Complex I, II and IV couple electron transfer to proton transport across the inner mitochondrial membrane into the inner membrane space. This generates a proton electrochemical gradient which is used to drive the synthesis of ATP from ADP and inorganic phosphate by ATP synthase (Complex V). (Adapted from PMID:23356252 and PMID:11331900.)

Protein Function (UniProtKB)

(UniProt, P03896)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mt:ND2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P03896)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mt:ND2-RA

FBtr0100857

1024

341

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

mt:ND2-PA

FBpp0100175

39.8

341

9.55

P03896

NP_008277

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mt:ND2 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of respiratory chain complex I

inferred from direct assay

(Agip et al., 2023)

inferred from mutant phenotype

(Burman et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mt:ND2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mt:ND2

View exonic expression by tissue for Dmel\mt:ND2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

192474/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013680

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013680

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mt:ND2

Transgenic constructs containing regulatory region of mt:ND2

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal flight

mt:ND2^del1

abnormal heat stress response

mt:ND2^del1

abnormal neuroanatomy | progressive

mt:ND2^del1

abnormal stress response

mt:ND2^del1

bang sensitive | progressive

mt:ND2^del1

short lived

mt:ND2^del1

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\ND2

13 of 14

Yes

Hsap\ND5

2 of 14

Hsap\ND4

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\ND2

13 of 14

Yes

Rnor\ND5

2 of 14

Rnor\ND4

1 of 14

Mus musculus (laboratory mouse) (3)

Mmus\ND2

12 of 14

Yes

Mmus\ND5

2 of 14

Mmus\ND4

1 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\ND2

10 of 13

Yes

Xtro\ND4

1 of 13

Danio rerio (Zebrafish) (3)

Drer\ND2

13 of 14

Yes

Drer\ND5

2 of 14

Drer\ND4

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\ND2

4 of 14

Yes

Cele\ND5

1 of 14

Anopheles gambiae (African malaria mosquito) (3)

Agam\ND2

10 of 12

Yes

Agam\AgaP_AGAP012727

1 of 12

Agam\ND5

1 of 12

Arabidopsis thaliana (thale-cress) (4)

Atha\ndhB

8 of 13

Yes

Atha\AT2G07689

5 of 13

Yes

Atha\ndhD

1 of 13

Atha\ndhF

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (7)

Ecol\nuoN

9 of 11

Yes

Ecol\hyfF

3 of 11

Yes

Ecol\hycC

1 of 11

Yes

Ecol\hyfB

1 of 11

Yes

Ecol\hyfD

1 of 11

Yes

Ecol\nuoL

1 of 11

Ecol\nuoM

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mt:ND2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial complex I disorders, MT-ND2-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

mt:ND2^del1

model of mitochondrial metabolism disease

CEA

(Burman et al., 2014)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MT-ND2; mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

13 of 14

516001

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

mt:ND2 - mle

anti tag coimmunoprecipitation, full identification by RNA sequencing

(Müller et al., 2020)

protein-protein

Physical Interaction

Assay

References

mt:ND2 - ND-13A

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-13B

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-15

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-19

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-20

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-23

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-24

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-30

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-39

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-42

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-51

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-75

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-ACP

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-AGGG

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-ASHI

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B12

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B14

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B14.5A

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B14.5B

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B14.7

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B15

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B16.6

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B17

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B17.2

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B18

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-B22

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-MNLL

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-MWFE

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-PDSW

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - ND-SGDH

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - NP15.6

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - NdufA3

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - mt:ND1

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - mt:ND3

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - mt:ND4L

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - mt:ND5

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

mt:ND2 - mt:ND6

cosedimentation, electron microscopy, molecular weight estimation by staining

(Padavannil et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

OXIDATIVE PHOSPHORYLATION

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

aerobic respiration I (cytochrome c)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

mt_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

mitochondrion_genome

Recombination map

Cytogenetic map

Sequence location

mitochondrion_genome:240..1,263 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

95254

w^*; mt:ND2^del1

77154

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05920}attP40

VDRC

v109217

P{KK116148}VIE-260B

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013680

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Murari et al., 2020)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG34063) in release 4.3 of the genome annotation.

(FlyBase Genome Annotators, 2005)

mt:ND2 has been cloned and sequenced, and compared to Dsim\mt:ND2, Dsec\mt:ND2 and Dmau\mt:ND2.

(Satta and Takahata, 1990)

During oogenesis RNA from mt:srRNA, mt:lrRNA, mt:ND2, mt:CoI, mt:CoII, mt:CoIII, mt:ND4, mt:ND5 and mt:Cyt-b shows fluctuations in RNA density after stage 9 in follicle and nurse cells.There is a correlation between the mtRNA level and the cell volume and/or the nuclear DNA content suggesting a global extra-mitochondrial, transcriptional control mechanism.

(Tourmente et al., 1990)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG34063

(Murari et al., 2023, Ibaraki et al., 2021, Murari et al., 2020, Rhooms et al., 2020, Palu and Thummel, 2016, Foriel et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2005)

URF2

dND2

(Murari et al., 2023, Murari et al., 2022, Murari et al., 2021, Murari et al., 2020, Rhooms et al., 2020)

mt:nd2

(Lieber et al., 2019)

nad2

(Aradska et al., 2015, Stewart and Beckenbach, 2009)

nd2

(Baggio et al., 2014, Torres et al., 2009)

Name Synonyms

Mitochondrial NADH-ubiquinone

(Mossman et al., 2016)

NADH dehydrogenase subunit 2

(Burman et al., 2014, Ballard, 2000)

mitochondrial NADH-ubiquinone oxidoreductase chain 2

oxidoreductase chain 2

(Mossman et al., 2016)

Secondary FlyBase IDs

FBgn0002867

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

192474

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

NP_008277

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P03896

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P03896

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7GHL2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P03896

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

192474/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013680

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013680

FlyMine - An integrated database for Drosophila genomics

FBgn0013680

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34063

MARRVEL_MODEL - MARRVEL (model organism gene)

192474

PDB - An information portal to biological macromolecular structures

Linkouts

DRSC - Results frm RNAi screens

FBgn0013680

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013680

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

aerobic respiration I (cytochrome c)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (130)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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