FlyBase Gene Report: Dmel\Dhc93AB

General Information

Symbol

Dmel\Dhc93AB

Species

D. melanogaster

Name

Dynein heavy chain at 93AB

Annotation Symbol

CG3723

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013812

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

Gene Summary

Dynein heavy chain at 93AB (Dhc93AB) encodes a motor protein involved in hearing. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Dhc 93AB, Dhc

Key Links

Genomic Location

Cytogenetic map

93B4-93B7

Sequence location

3R:21,024,580..21,042,499 [-]

Recombination map

3-70

RefSeq locus

NT_033777 REGION:21024580..21042499

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR035699

(InterPro Project Members, 2004-)

enables dynein intermediate chain binding

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

enables dynein light intermediate chain binding

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

enables minus-end-directed microtubule motor activity

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR004273

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P45444

(Gene Ontology Curators, 2002-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in sensory perception of sound

inferred from mutant phenotype

(Senthilan et al., 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cilium movement involved in cell motility

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

involved_in cilium movement

inferred from sequence or structural similarity with UniProtKB:Q9NYC9

(Gene Ontology Curators, 2002-)

involved_in microtubule-based movement

inferred from electronic annotation with InterPro:IPR004273, InterPro:IPR026983

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in 9+2 motile cilium

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

is_active_in axoneme

inferred from biological aspect of ancestor with PANTHER:PTN000073047

(GO Reference Genome Project, 2011-)

part_of dynein complex

inferred from electronic annotation with InterPro:IPR004273, InterPro:IPR026983

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

part_of outer dynein arm

inferred from sequence or structural similarity with UniProtKB:B1AR51

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

AXONEMAL OUTER ARM DYNEIN HEAVY CHAINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

minus-end-directed microtubule motor activity

Summaries

Gene Snapshot

Dynein heavy chain at 93AB (Dhc93AB) encodes a motor protein involved in hearing. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

AXONEMAL OUTER ARM DYNEIN HEAVY CHAINS -: Dynein heavy chains are minus end-directed microtubule motor proteins. Axonemal dynein complexes interact with adjacent microtubules in the axoneme. Coordinated binding and release of the axonemal dyneins slide the microtubules relative to each other causing the axoneme to bend driving ciliary and flagellar motion. Axonemal outer arm dynein heavy chains are the microtubule-binding motor protein of the dynein outer arm. (Adapted from FBrf0230280).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dhc93AB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KHJ4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dhc93AB-RB

FBtr0273236

NM_079700

13980

4486

Dhc93AB-RC

FBtr0336774

NM_001275864

14010

4496

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dhc93AB-PB

FBpp0271744

514.0

4486

5.14

FBpp0307750

515.0

4496

5.15

A0A0B4KHJ4

NP_001262793

AGB96173

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dhc93AB using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.78

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

chordotonal neuron

(Zur Lage et al., 2019)

embryonic stage 15

chordotonal organ precursor cell

(Newton et al., 2012)

adult stage

Johnston organ

(Senthilan et al., 2012)

mutational analysis

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

chordotonal neuron

(Zur Lage et al., 2019)

pcr

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Rasmusson et al., 1994)

adult stage | female

(Rasmusson et al., 1994)

adult stage | male

(Rasmusson et al., 1994)

Additional Descriptive Data

As part of a survey of ciliary motility gene homologs in Drosophila, expression of Dhc93AB was assayed in motile ciliated cell types. Expression was observed in chordotonal neurons but not testis (sperm).

(Zur Lage et al., 2019)

Dhc93AB transcripts are detected in males, females and embryos by RT-PCR.

(Rasmusson et al., 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Dhc93AB-GAL4.S}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

Johnston organ neuron

(Senthilan et al., 2012)

Reporter: P{Dhc93AB-GFP.820}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

chordotonal organ precursor cell

(Newton et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dhc93AB in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dhc93AB

View exonic expression by tissue for Dmel\Dhc93AB

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42485/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013812

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013812

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013812

Flygut - An atlas of the Drosophila adult midgut

FBgn0013812

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dhc93AB

Transgenic constructs containing regulatory region of Dhc93AB

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6272

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

Dhc93AB^GD11054

viable, with Scer\GAL4^pnr-MD237

Dhc93AB^GD11054

viable, with Scer\GAL4^tin.CΔ4

Dhc93AB^GD11054

Sterility

Allele

male fertile, with Scer\GAL4^VP16.bam

Dhc93AB^KK100610

Other Phenotypes

Allele

abnormal adult locomotory behavior, with Scer\GAL4^sca-537.4

Dhc93AB^KK100610

abnormal auditory perception | adult stage

Dhc93AB^MB05444

abnormal locomotor behavior | adult stage, with Scer\GAL4^sca.PU

Dhc93AB^KK100610

abnormal neurophysiology | adult stage

Dhc93AB^MB05444

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\DNAH9

13 of 14

Yes

Hsap\DNAH17

11 of 14

Yes

8 of 14

5 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Hsap\DYNC2H1

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Dnah9

13 of 14

Yes

Rnor\Dnah17

10 of 14

Yes

Rnor\Dnah11

7 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Dnhd1

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Dnah9

13 of 14

Yes

Mmus\Dnah17

10 of 14

Yes

8 of 14

5 of 14

5 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Map1lc3b

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\dnah9

10 of 13

Yes

Xtro\LOC100497531

5 of 13

Xtro\dnah11

4 of 13

Yes

Xtro\dnah2

3 of 13

Xtro\dnah10

3 of 13

Xtro\dnah14

3 of 13

Yes

Xtro\dnah6

2 of 13

Xtro\spred1

2 of 13

Xtro\c1orf159

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rab19

1 of 13

Xtro\sbf2

1 of 13

Xtro\zswim7

1 of 13

Yes

Danio rerio (Zebrafish) (16)

Drer\dnah9l

9 of 14

Yes

7 of 14

4 of 14

4 of 14

3 of 14

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\dnah3

1 of 14

Drer\LOC110439139

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\che-3

4 of 14

Yes

Cele\dhc-1

4 of 14

Yes

Cele\dhc-3

1 of 14

Cele\dhc-4

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP010435

12 of 12

Yes

6 of 12

4 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\DYN1

4 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\dhc1

5 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dhc93AB. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (14)

9 of 13

9 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

7 of 13

btv

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

sac

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Dhc93AB^MB05444

model of sensorineural hearing loss

CEA

(Senthilan et al., 2012)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

DNAH9; dynein axonemal heavy chain 9

model of primary ciliary dyskinesia 40

IEA

(FlyBase, 2019-)

DNAH17; dynein axonemal heavy chain 17

model of spermatogenic failure 39

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Dhc93AB^GD11054

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DNAH9; dynein axonemal heavy chain 9

13 of 14

603330

CILIARY DYSKINESIA, PRIMARY, 40; CILD40

primary ciliary dyskinesia 40

DNAH17; dynein axonemal heavy chain 17

11 of 14

610063

SPERMATOGENIC FAILURE 39; SPGF39

spermatogenic failure 39

DNAH11; dynein axonemal heavy chain 11

8 of 14

603339

CILIARY DYSKINESIA, PRIMARY, 7; CILD7

primary ciliary dyskinesia 7

DNAH2; dynein axonemal heavy chain 2

5 of 14

603333

SPERMATOGENIC FAILURE 45; SPGF45

spermatogenic failure 45

DNAH6; dynein axonemal heavy chain 6

4 of 14

603336

DNAH10; dynein axonemal heavy chain 10

4 of 14

605884

SPERMATOGENIC FAILURE 56; SPGF56

spermatogenic failure 56

DNAH1; dynein axonemal heavy chain 1

3 of 14

603332

DNAH3; dynein axonemal heavy chain 3

3 of 14

603334

DNAH5; dynein axonemal heavy chain 5

3 of 14

603335

CILIARY DYSKINESIA, PRIMARY, 3; CILD3

primary ciliary dyskinesia 3

DNAH7; dynein axonemal heavy chain 7

3 of 14

610061

CILIARY DYSKINESIA, PRIMARY, 50; CILD50

DNAH8; dynein axonemal heavy chain 8

3 of 14

603337

SPERMATOGENIC FAILURE 46; SPGF46

spermatogenic failure 46

DNAH12; dynein axonemal heavy chain 12

3 of 14

603340

SPERMATOGENIC FAILURE 100; SPGF100

DNAH14; dynein axonemal heavy chain 14

3 of 14

603341

DYNC1H1; dynein cytoplasmic 1 heavy chain 1

3 of 14

600112

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dhc93AB - Nuf2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2007)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0013812

MIST (protein-protein) - An integrated Molecular Interaction Database

42485

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-70

Cytogenetic map

93B4-93B7

Sequence location

3R:21,024,580..21,042,499 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93B4-93B7

; Limits computationally determined from genome sequence between P{PZ}Atpα⁰¹¹⁶⁴ and P{PZ}mod(mdg4)⁰⁷⁰³⁸&P{lacW}mod(mdg4)^L3101

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

93A-93B

(Li, 1993)

93A-93B

(determined by in situ hybridisation)

(Rasmusson et al., 1994)

Experimentally Determined Recombination Data

Location

3-70

(FlyBase, 2016)

3-73.4

(Comeron et al., 2012)

(Li, 1993)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25298

w¹¹¹⁸; Mi{ET1}Dhc93AB^MB05444

51511

y¹ v¹; P{TRiP.HMC03281}attP2

37789

y¹ w^*; Mi{MIC}Dhc93AB^MI03486

80583

y¹ w^*; TI{CRIMIC.TG4.2}Dhc93AB^{CR00454-TG4.2}

NIG-Fly

3723R-2

P{NIG.3723R}2

3723R-3

P{NIG.3723R}3

HMC03281

y¹ v¹; P{TRiP.HMC03281}attP2

VDRC

v108658

P{KK100610}VIE-260B

v41947

w¹¹¹⁸; P{GD11054}v41947/TM3

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013812

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Spindle pole movements in embryos are directed by a temporally coordinated balance of forces generated by three mitotic motors; cytoplasmic dynein, Klp61F and ncd. Dynein acts to move the poles apart throughout mitosis, and this activity is augmented by Klp61F after the fenestration of the nuclear envelope, which occurs at the onset of prometaphase. ncd generates forces that pull the poles together between interphase and metaphase, antagonising the activity of both cytoplasmic dynein and Klp61F and serving as a brake for spindle assembly.

(Sharp et al., 2000)

Identification: PCR screen for Dynein heavy chain genes.

(Kurek et al., 1998)

Dhc93AB has been cloned and characterised.

(Rasmusson et al., 1994)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Dhc93AB CG3723

(Gong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG3723

(Xiang et al., 2022, Kumar et al., 2016, Butzlaff et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Laurençon et al., 2007, Przewloka et al., 2007, Wickstead and Gull, 2007, Buenemann, 2002.3.21, Goldstein and Gunawardena, 2000)

DHC

(Cytrynbaum et al., 2003, Sharp et al., 2000)

DHC4C

(Kollmar, 2015.9.15)

Dhc

(Johnstone and Lasko, 2001, Starr et al., 1998)

Dhc 93AB

(Du et al., 2021, Diaz-Castillo and Golic, 2007)

Dhc93AB

(Williams-Simon et al., 2024, Xiang et al., 2022, Zur Lage et al., 2019, Levis, 2018.8.30, Butzlaff et al., 2015, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Newton et al., 2012, Senthilan et al., 2012, Wasbrough et al., 2010, Junion et al., 2007, Laurençon et al., 2007, Dorus et al., 2006)

dhc

(Basto et al., 2004)

dhc93AB

(Butzlaff et al., 2015)

Name Synonyms

Dynein heavy chain at 93AB

dynein-related heavy chain polypeptide

(Li, 1993)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42485

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

L23198

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KHJ4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KHJ4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42485/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013812

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013812

FlyMine - An integrated database for Drosophila genomics

FBgn0013812

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3723

MARRVEL_MODEL - MARRVEL (model organism gene)

42485

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0013812

DRSC - Results frm RNAi screens

FBgn0013812

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013812

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013812

Flygut - An atlas of the Drosophila adult midgut

FBgn0013812

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010846

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

MIST (protein-protein) - An integrated Molecular Interaction Database

42485

References (56)

The following external sites may use different assemblies or annotations than FlyBase.

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