FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Surf4
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General Information
Symbol
Dmel\Surf4
Species
D. melanogaster
Name
Surfeit 4
Annotation Symbol
CG6202
Feature Type
protein_coding_gene
FlyBase ID
FBgn0019925
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. (UniProt, O18405)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
88F1-88F1
Sequence location
Recombination map
3-57
RefSeq locus
NT_033777 REGION:15343653..15346176
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in Golgi organization
inferred from biological aspect of ancestor with PANTHER:PTN000603682
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in endoplasmic reticulum-Golgi intermediate compartment
inferred from biological aspect of ancestor with PANTHER:PTN000603682
(GO Reference Genome Project, 2011-)
is_active_in endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN000603682
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR002995
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the SURF4 family. (O18405)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion.
(UniProt, O18405)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Surf4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O18405)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Surf4-RA
FBtr0083117
NM_057874
1641
270
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Surf4-PA
FBpp0082571
30.5
270
9.31
O18405
NP_477222
AAF55176
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

270 (aa)

(Armes and Fried, 1996)
Comments
External Data
Domain

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

(UniProt, O18405)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Surf4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.27

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008)
Expression Deduced from Reporters
Reporter: P{PTT-GC}Surf4CC01684
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
germarium
• fusome
(Lighthouse et al., 2008)
adult stage | male
male germline cyst
• fusome
(Lighthouse et al., 2008)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Surf4 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Surf4
Transgenic constructs containing regulatory region of Surf4
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel6174
(Ryder, 2004.4.26)
Inferred from location ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\SURF4
14 of 14
Yes
Yes
Hsap\SURF1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Surf4
9 of 14
Yes
Yes
Rnor\Surf1
2 of 14
No
No
Mus musculus (laboratory mouse) (2)
Mmus\Surf4
13 of 14
Yes
Yes
Mmus\Surf1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\surf4.1
10 of 13
Yes
Yes
Xtro\surf4.2
7 of 13
No
Yes
Xtro\surf1
1 of 13
No
No
Xtro\trim3
1 of 13
No
No
Xtro\ttc9b
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\surf4
13 of 14
Yes
Yes
Drer\surf4l
13 of 14
Yes
Yes
Drer\surf1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\sft-4
14 of 14
Yes
Yes
Cele\T02E1.7
7 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP001069
12 of 12
Yes
Yes
Agam\AgaP_AGAP006533
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT1G48510
1 of 13
Yes
No
Atha\SURF1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ERV29
13 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPCC970.06
12 of 12
Yes
Yes
Spom\shy1
1 of 12
No
No
Escherichia coli (enterobacterium) (2)
Ecol\yphA
1 of 11
Yes
Yes
Ecol\yqjF
1 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Surf4. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
CG17207
3 of 13
Surf1
3 of 13
CG14070
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SURF4; surfeit 4
    14 of 14
    185660
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Surf4 - CG13220
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - CG13887
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - CG15098
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - CG2070
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - CG3164
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - CG31729
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - CG5447
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - CG8195
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Cds
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - KdelR
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Kr-h2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - MRP
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Mcad
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Mec2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Ost48
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - OstΔ
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Ostγ
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Rdh1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Rer1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - SERCA
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Sec61α
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Tango9
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Tapδ
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - Tecr
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - ZnT63C
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - fax
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - grh
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Surf4 - jagn
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - porin
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - spidey
        experimental knowledge based
        (Guruharsha et al., 2011)
        Surf4 - sun
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-57
        Cytogenetic map
        88F1-88F1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        88F1-88F1
        Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        88F-88F
        (Fried, 1997.9.15)
        88F3-88F4
        (determined by in situ hybridisation)
        (Armes and Fried, 1996)
        Experimentally Determined Recombination Data
        Location

        3-57

        (FlyBase, 2016)

        3-56.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (300)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              In mouse the Surfeit locus contains six Surf genes in a tight gene cluster. In Drosophila Surf4 is not closely associated with other Surfeit gene homologs.

              (Armes and Fried, 1996)
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: Surf4 CG6202

              (Zheng, 1999.11)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (5)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 38 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (60)