FlyBase Gene Report: Dmel\CG40191

General Information

Symbol

Dmel\CG40191

Species

D. melanogaster

Name

Annotation Symbol

CG40191

Feature Type

protein_coding_gene

FlyBase ID

FBgn0058191

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

41A1-41A1

Sequence location

2R:1,264,140..1,267,747 [+]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:1264140..1267747

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase regulator activity

inferred from biological aspect of ancestor with PANTHER:PTN000401404

(GO Reference Genome Project, 2011-)

enables protein kinase binding

inferred from electronic annotation with InterPro:IPR013922

(InterPro Project Members, 2004-)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of cyclin-dependent protein kinase holoenzyme complex

inferred from biological aspect of ancestor with PANTHER:PTN000401404

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000401404

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG40191 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7PLT1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG40191-RA

FBtr0113825

NM_001015175

2923

378

CG40191-RB

FBtr0113824

NM_001015174

1579

396

CG40191-RC

FBtr0113827

NM_001015176

1518

378

CG40191-RD

FBtr0113826

NM_001110883

1386

378

CG40191-RE

FBtr0334735

NM_001276226

1203

268

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG40191-PA

FBpp0112548

43.0

378

6.71

FBpp0112547

45.2

396

7.49

FBpp0112550

43.0

378

6.71

FBpp0112549

43.0

378

6.71

FBpp0306783

30.6

268

5.39

D3DMV3

NP_001263155

ELP57400

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

378 aa isoforms: CG40191-PA, CG40191-PC, CG40191-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG40191 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.91

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG40191 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG40191

View exonic expression by tissue for Dmel\CG40191

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0058191

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3354930/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0058191

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0058191

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0058191

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG40191

Flygut - An atlas of the Drosophila adult midgut

FBgn0058191

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG40191

Transgenic constructs containing regulatory region of CG40191

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\CNPPD1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Cnppd1

11 of 14

Yes

Rnor\Ccnyl1

1 of 14

Rnor\Ccny

1 of 14

Mus musculus (laboratory mouse) (3)

Mmus\Cnppd1

9 of 14

Yes

Mmus\Ccnyl1

1 of 14

Mmus\Ccny

1 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\cnppd1

6 of 13

Yes

Xtro\ccdc9

1 of 13

Yes

Xtro\ccnyl1

1 of 13

Xtro\ccny

1 of 13

Danio rerio (Zebrafish) (3)

Drer\cnppd1

10 of 14

Yes

Drer\ccny

1 of 14

Drer\ccnyl1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\F09G2.2

10 of 14

Yes

Cele\cyy-1

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP009020

11 of 12

Yes

Agam\AgaP_AGAP008969

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\CYCP2;1

3 of 13

Yes

Atha\cycp3;1

3 of 13

Yes

Atha\CYCP3;2

3 of 13

Yes

Atha\AT3G05327

2 of 13

Yes

Atha\CYCP1;1

2 of 13

Atha\CYCP4;1

2 of 13

Yes

Atha\CYCP4;2

2 of 13

Yes

Atha\CYCP4;3

2 of 13

Yes

Atha\ATN

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\PCL6

4 of 13

Yes

Scer\PCL7

4 of 13

Yes

Scer\PCL8

4 of 13

Yes

Scer\PCL10

4 of 13

Yes

Scer\PHO80

4 of 13

Yes

Scer\PCL1

2 of 13

Yes

Scer\PCL2

2 of 13

Yes

Scer\PCL9

2 of 13

Yes

Scer\CLG1

1 of 13

Yes

Scer\PCL5

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\psl1

3 of 12

Yes

Spom\pas1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG40191. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

CycY

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CNPPD1; cyclin Pas1/PHO80 domain containing 1

11 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0058191

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

41A1-41A1

Sequence location

2R:1,264,140..1,267,747 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

41A1-41A1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

h41-h42

(determined by in situ hybridisation)

(Rossi et al., 2007)

h35-h46

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-55.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

62023

y¹ w^67c23; P{SUPor-P}CG40191^KG07815

62029

y¹ w^67c23; P{SUPor-P}CG40191^KV00004/SM6a

VDRC

v107687

P{KK113613}VIE-260B

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (9)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0058191

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0058191

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG40191) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG40191 BEST:HL02313

(FlyBase, 1996-)

Source for merge of: CG40191 BcDNA:LD12604

(FlyBase, 1996-)

Additional comments

Source for merge of CG40191 BcDNA:LD12604 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

BEST:HL02313

BcDNA:LD12604

CG40191

(Vrailas-Mortimer et al., 2021, Funikov et al., 2020, Caizzi et al., 2016, Keleman et al., 2009.8.5, Drosophila Heterochromatin Genome Project, 2007, Rossi et al., 2007)

Name Synonyms

Secondary FlyBase IDs

FBgn0043801
FBgn0063162
FBan0040191

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3354930

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7PLT1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7PLT1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0058191

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3354930/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0058191

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0058191

FlyMine - An integrated database for Drosophila genomics

FBgn0058191

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG40191

MARRVEL_MODEL - MARRVEL (model organism gene)

3354930

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0058191

DroID - A comprehensive database of gene and protein interactions.

FBgn0058191

DRSC - Results frm RNAi screens

FBgn0058191

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0058191

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0058191

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG40191

Flygut - An atlas of the Drosophila adult midgut

FBgn0058191

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012803

References (16)

The following external sites may use different assemblies or annotations than FlyBase.

-0.91

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