FlyBase Gene Report: Dmel\kmr

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kmr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 7 -- 8

hindgut anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kmr in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kmr

View exonic expression by tissue for Dmel\kmr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085412

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740131/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085412

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085412

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085412

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9322

Flygut - An atlas of the Drosophila adult midgut

FBgn0085412

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\kmr

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kmr

Transgenic constructs containing regulatory region of kmr

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6170

(Shami Shah et al., 2019, Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

kmr^GD8307

viable

kmr^f01731

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

kmr^GD8306

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

kmr^f01731

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kmr^GD8306

abnormal planar polarity | adult stage (with Df(3R)Exel6170)

abnormal planar polarity | adult stage | recessive

abnormal planar polarity | pupal stage

some die during pupal stage, with Scer\GAL4^pnr-MD237

kmr^GD8307

visible | adult stage (with Df(3R)Exel6170)

visible | adult stage | recessive

Phenotype manifest in

Allele

interommatidial bristle

notum

trichome

wing disc | pupal stage

wing hair

wing hair (with Df(3R)Exel6170)

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

Hsap\PLEKHA6

5 of 14

Yes

Hsap\PLEKHA7

5 of 14

Yes

Hsap\PLEKHA4

4 of 14

Yes

Hsap\PLEKHA5

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PLEKHA1

1 of 14

Yes

Hsap\PLEKHA2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PLEK

1 of 14

Yes

Hsap\RASGRF1

1 of 14

Hsap\RASGRF2

1 of 14

Hsap\SWAP70

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (31)

Rnor\Plekha4

5 of 14

Yes

Rnor\Plekha5

5 of 14

Yes

Rnor\Plekha7

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Def6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Plekha1

1 of 14

Yes

Rnor\Plekha2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Plek

1 of 14

Yes

Rnor\Rasgrf1

1 of 14

Yes

Rnor\Rasgrf2

1 of 14

Yes

Rnor\RGD1560925

1 of 14

Mus musculus (laboratory mouse) (32)

Mmus\Plekha4

5 of 14

Yes

Mmus\Plekha5

5 of 14

Yes

Mmus\Plekha7

5 of 14

Yes

Mmus\Plekha6

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Def6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Plekha1

1 of 14

Yes

Mmus\Plekha2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Plek

1 of 14

Yes

Mmus\Rasgrf1

1 of 14

Mmus\Rasgrf2

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (15)

Xtro\plekha4

4 of 13

Yes

Xtro\plekha7

4 of 13

Yes

Xtro\plekha5

2 of 13

Yes

Xtro\plekha6

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gab2

1 of 13

Xtro\LOC108648942

1 of 13

Yes

Xtro\myo10.2

1 of 13

Xtro\plekha1

1 of 13

Yes

Xtro\plekhj1

1 of 13

Xtro\rasgrf2

1 of 13

Yes

Xtro\skap2

1 of 13

Yes

Danio rerio (Zebrafish) (47)

Drer\plekha7a

6 of 14

Yes

Drer\plekha7b

6 of 14

Yes

Drer\si:ch211-234p6.5

5 of 14

Yes

Drer\plekha5

4 of 14

Yes

Drer\plekha6

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\def6a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\plekha1a

1 of 14

Yes

Drer\plekha1b

1 of 14

Yes

Drer\plekha2

1 of 14

Yes

Drer\plekhh1

1 of 14

Drer\plekhj1

1 of 14

Drer\plekhs1.1

1 of 14

Yes

Drer\plekhs1.2

1 of 14

Yes

Drer\plekhs1.3

1 of 14

Yes

Drer\plekhs1.4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\cnt-1

1 of 14

Yes

Cele\grp-1

1 of 14

Yes

Cele\Y37D8A.25

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP005285

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\AT5G05710

2 of 13

Yes

Atha\PH1

2 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\BOI1

2 of 13

Yes

Scer\BOI2

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:kmr. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

CG43707

2 of 13

Akt

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

osp

1 of 13

step

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PLEKHA6; pleckstrin homology domain containing A6

5 of 14

607771

PLEKHA7; pleckstrin homology domain containing A7

5 of 14

612686

PLEKHA4; pleckstrin homology domain containing A4

4 of 14

607769

PLEKHA5; pleckstrin homology domain containing A5

4 of 14

607770

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

624762

DroID - A comprehensive database of gene and protein interactions.

FBgn0085412

MIST (protein-protein) - An integrated Molecular Interaction Database

5740131

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PIPs at the plasma membrane

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PIPs at the plasma membrane

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-54

Cytogenetic map

87F12-87F13

Sequence location

3R:13,715,207..13,764,667 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87F12-87F13

Limits computationally determined from genome sequence between P{PZ}flfl⁰¹⁹⁴⁹ and P{lacW}trx^j14A6&P{PZ}trx⁰⁰³⁴⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-54

(FlyBase, 2016)

3-51.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18465

w¹¹¹⁸; PBac{WH}kmr^f01731

24325

w¹¹¹⁸; Mi{ET1}kmr^MB05180

65715

w¹¹¹⁸; PBac{IT.GAL4}kmr^2066-G4

41111

y¹ w^*; Mi{MIC}kmr^MI06872

14055

y¹ w^67c23; ry⁵⁰⁶ P{SUPor-P}kmr^KG06885

51917

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03376}attP2

Kyoto

122062

w¹¹¹⁸; P{EP}kmr^EP3512

14366R-1

14366R-2

v29100

w¹¹¹⁸ P{GD14186}v29100

v38786

w¹¹¹⁸; P{GD8306}v38786

v38787

w¹¹¹⁸; P{GD8306}v38787

More stocks available...

Genomic Clones (41)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (66)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH13441

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085412

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085412

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG14365 CG14366 CG9322

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG14365, CG14366 and CG9322 merged as CG34383 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: kmr CG34383

(Shami Shah et al., 2019)

Nomenclature comments

Etymology

Named 'kramer', due to the irregular hair patterning in mutants.

(Shami Shah et al., 2019)

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG14365

CG14366

(Manak et al., 2006)

CG34383

(Pang et al., 2021, Shami Shah et al., 2019, Li-Kroeger et al., 2018, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Ni et al., 2010.12.1, Wasbrough et al., 2010, FlyBase Genome Annotators, 2007)

CG9322

Dm_3R:52023

(FlyBase Genome Annotators, 2014, Ladoukakis et al., 2011)

PLEKHA4

(Shami Shah et al., 2019)

kmr

(Sun et al., 2024, Shami Shah et al., 2019)

Name Synonyms

CG14365

CG14366

CG9322

Kramer

(Harrison et al., 2020)

kramer

(Shami Shah et al., 2019)

Secondary FlyBase IDs

FBgn0038177
FBgn0038176
FBgn0038178

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 70 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5740131

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8JR01

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8JR01

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085412

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740131/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085412

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085412

FlyMine - An integrated database for Drosophila genomics

FBgn0085412

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34383

MARRVEL_MODEL - MARRVEL (model organism gene)

5740131

Linkouts

BioGRID - A database of protein and genetic interactions.

624762

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085412

DroID - A comprehensive database of gene and protein interactions.

FBgn0085412

DRSC - Results frm RNAi screens

FBgn0085412

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085412

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085412

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9322

Flygut - An atlas of the Drosophila adult midgut

FBgn0085412

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0085412

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010799

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

5740131

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PIPs at the plasma membrane

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PIPs at the plasma membrane

References (50)

The following external sites may use different assemblies or annotations than FlyBase.

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