FlyBase Gene Report: Dmel\CG43897

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43897 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

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Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG43897 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43897

View exonic expression by tissue for Dmel\CG43897

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264489

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39153/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264489

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264489

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43897

Transgenic constructs containing regulatory region of CG43897

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Ilp1-5

(Zhang et al., 2009)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

CG43897^GD10441

viable, with Scer\GAL4^pnr-MD237

CG43897^GD10443

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

CG43897^GD10443

visible, with Scer\GAL4^pnr-MD237

CG43897^GD10443

Phenotype manifest in

Allele

chaeta | increased number, with Scer\GAL4^pnr-MD237

CG43897^GD10443

mesonotum, with Scer\GAL4^pnr-MD237

CG43897^GD10443

trichogen cell | increased number, with Scer\GAL4^pnr-MD237

CG43897^GD10443

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\SMPD1

1 of 14

Yes

Hsap\SMPDL3A

1 of 14

Yes

Hsap\SMPDL3B

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Smpd1

1 of 14

Yes

Rnor\Smpdl3a

1 of 14

Yes

Rnor\Smpdl3b

1 of 14

Yes

Mus musculus (laboratory mouse) (3)

Mmus\Smpd1

1 of 14

Yes

Mmus\Smpdl3a

1 of 14

Yes

Mmus\Smpdl3b

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\pdlim1

1 of 13

Yes

Xtro\pdlim3

1 of 13

Yes

Xtro\pdlim4

1 of 13

Yes

Xtro\sphk2

1 of 13

Yes

Danio rerio (Zebrafish) (3)

Drer\smpd1

1 of 14

Yes

Drer\smpdl3a

1 of 14

Yes

Drer\smpdl3b

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\asm-1

1 of 14

Yes

Cele\asm-2

1 of 14

Yes

Cele\ZK856.5

1 of 14

Yes

Cele\ZK856.18

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP005807

4 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PPN1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBC713.07c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG43897. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

Asm

1 of 13

CG15533

1 of 13

CG15534

1 of 13

CG32052

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CG43897 - CG10209

two hybrid

(Hu et al., 2017.6.13)

CG43897 - CG44251

two hybrid

(Hu et al., 2017.6.13)

CG43897 - Su(dx)

two hybrid

(Hu et al., 2017.6.13)

CG43897 - Traf-like

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264489

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-31

Cytogenetic map

67C9-67C10

Sequence location

3L:9,813,847..9,834,345 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67C9-67C10

Limits computationally determined from genome sequence between P{PZ}fry⁰²²⁴⁰ and P{lacW}l(3)L0539^L0539&P{PZ}Dhh1^rL562

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-31

(FlyBase, 2016)

3-24.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

74277

w¹¹¹⁸; P{VT028270-p65.AD}attP40

75468

w¹¹¹⁸; P{VT028270-GAL4.DBD}attP2

31560

y¹ v¹; P{TRiP.JF01132}attP2

26443

w¹¹¹⁸; Mi{ET1}CG43897^MB09138

40247

y¹ w^*; Mi{MIC}CG43897^MI06320

87229

w¹¹¹⁸; P{VT028270-p65.AD}attP40; P{R20H05-GAL4.DBD}attP2

89516

w¹¹¹⁸; P{R60G04-p65.AD}attP40; P{VT028270-GAL4.DBD}attP2

Korea

13277

P{VT028270-GAL4}attP2

32049R-1

32049R-2

v102222

v109901

More stocks available...

Genomic Clones (27)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (270)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RH19933

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264489

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG33205 BcDNA:RE55923

(FlyBase, 1996-)

Source for merge of: CG33205 BcDNA:RH19933

(FlyBase, 1996-)

Source for merge of: CG32050 CG33205

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG32050 and CG33205 merged as CG43897 in release 5.45 of the genome annotation.

(FlyBase Genome Annotators, 2012)

Release 3 annotation CG32050 corresponds to the 3' portion of release 2 annotation CG14172. Release 3 annotation CG32052 corresponds to the 5' portion of release 2 annotation CG8163. Release 3 annotation CG33205 corresponds to the 3' end of release 2 annotation CG8163, 1 small exon of release 2 annotation CG14172 plus release 2 annotation CG8154.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG33205 BcDNA:RH19933 was a shared cDNA ( date:030728 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Source for merge of CG33205 BcDNA:RE55923 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BcDNA:RE55923

BcDNA:RH19933

CG14172

CG32049

CG32050

(Keleman et al., 2009.8.5, Haag-Liautard et al., 2007)

CG32051

CG33205

(Li et al., 2014, Irion, 2012, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Cammarato et al., 2011, Schrider et al., 2011, Keleman et al., 2009.8.5, Zhang et al., 2009, Ni et al., 2008, Wang et al., 2008)

CG43897

(Trujillo et al., 2024, Fisher et al., 2023, Li et al., 2023, Yang et al., 2023, Laskowski et al., 2022, Palu et al., 2022, Hu et al., 2017.6.13, Gene Disruption Project members, 2015-, Schleich et al., 2014, FlyBase Genome Annotators, 2012)

CG8154

(Dorner et al., 2006, Arbeitman et al., 2002, Furlong et al., 2001)

CG8163

Name Synonyms

Secondary FlyBase IDs

FBgn0052050
FBgn0036050
FBgn0053205
FBgn0036049
FBgn0036051
FBgn0052049
FBgn0052051
FBgn0064835
FBgn0064876

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 115 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39153

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PF57

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PF57

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264489

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39153/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264489

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264489

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43897

MARRVEL_MODEL - MARRVEL (model organism gene)

39153

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264489

DroID - A comprehensive database of gene and protein interactions.

FBgn0264489

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264489

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000576

References (53)

The following external sites may use different assemblies or annotations than FlyBase.

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