FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
vig, Fmr1
FlyBase ID
FBig0000098836
Interaction Network
Interactions Browser links
vig network
Fmr1 network
Reported Interactions
FBrf0152005-3.CH.MS
Reference
Caudy et al., 2002
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

dFXR1

neutral component
Fmr1 

dFXR1

neutral component
Fmr1 

dFXR1

neutral component
vig 

VIG

neutral component
vig 

VIG

neutral component
vig 

VIG

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

RISC activity was extracted from ribosomes, then fractionated by gel filtration and ion exchange chromatography.

(Caudy et al., 2002)

AGO2, Fmr1 and vig cofractionate as part of the RISC complex.

(Caudy et al., 2002)

Source was cell extract of S2 cell line; proteins produced from endogenous genes.

(Caudy et al., 2002)
FBrf0162256-11.coIP.WB
Reference
Caudy et al., 2003
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
vig 

VIG

bait
Fmr1 

FXR

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Caudy et al., 2003)
FBrf0162256-5.CH.WB
Reference
Caudy et al., 2003
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

FXR

neutral component
Fmr1 

FXR

neutral component
Fmr1 

FXR

neutral component
vig 

VIG

neutral component
vig 

VIG

neutral component
vig 

VIG

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

RISC activity was extracted from ribosomes, then fractionated by gel filtration and Source Q chromatography.

(Caudy et al., 2003)

AGO2, Tudor-SN, Fmr1 and vig cofractionate as part of the RISC complex.

(Caudy et al., 2003)

Source was cell extract of S2 cell line; proteins produced from endogenous genes.

(Caudy et al., 2003)
FBrf0206362-17.coIP.WB
Reference
Zhou et al., 2008
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
vig 

VIG

bait

FLAG tag

Fmr1 

FMR

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Zhou et al., 2008)
FBrf0240783-9.coIP.WB
Reference
Lee et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-ThermoFischer
Participants
Corresponds to
Reported as
Role
Note
vig 

VIG

bait

HA tag

Fmr1 

FMRP

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Lee et al., 2018)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (4)