Voelker, R.A., Langley, C.H., Leigh Brown, A.J., Ohnishi, S., Dickson, B., Montgomery, E., Smith, S.C. (1980). Enzyme null alleles in natural populations of Drosophila melanogaster: frequencies in a North Carolina population.  Proc. Natl. Acad. Sci. U.S.A. 77(2): 1091--1095.

FBrf0035524

Research paper

A Raleigh, NC, population of Drosophila melanogaster was sampled for the presence of enzyme null alleles at 25 loci. No nulls were found at any of five X-linked loci. Nulls were recovered at 13 of 20 autosomal loci; the weighted mean frequency for all 20 autosomal loci was estimated to be 0.0025. A consideration of the effects of these null alleles on viability strongly suggests that, although they may contribute to so-called polygenic variation, they are not representative of the entire genome.

PMC348430 (PMC) (EuropePMC)