Tansey, T., Schultz, J.R., Miller, R.C., Storti, R.V. (1991). Small differences in Drosophila tropomyosin expression have significant effects on muscle function. Mol. Cell. Biol. 11(): 6337--6342.
FlyBase ID
FBrf0054694
Publication Type
Research paper
Abstract
The effects of promoter deletions on Drosophila tropomyosin I (TmI) gene expression have been determined by measuring TmI RNA levels in transformed flies. Decreases in RNA levels have been correlated with rescue of flightless and jumpless mutant phenotypes in Ifm(3)3 mutant transformed flies and changes in muscle ultrastructure. The results of this analysis have allowed us to identify a region responsible for 20% of maximal TmI expression, estimate threshold levels of TmI RNA required for indirect flight and jump muscle function, and obtain evidence suggesting that sarcomere length may be an important determinant of flight muscle function.
