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Citation
Meller, V.H., Wu, K.H., Roman, G., Kuroda, M.I., Davis, R.L. (1997). roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system.  Cell 88(4): 445--457.
FlyBase ID
FBrf0092630
Publication Type
Research paper
Abstract

The Drosophila roX1 gene is X-linked and produces RNAs that are male-specific, somatic, and preferentially expressed in the central nervous system. These RNAs are retained in the nucleus and lack any significant open reading frame. Although all sexually dimorphic characteristics in Drosophila were thought to be controlled by the sex determination pathway through the gene transformer (tra), the expression of roX1 is independent of tra activity. Instead, the dosage compensation system is necessary and sufficient for the expression of roX1. Consistent with a potential function in dosage compensation, roX1 RNAs localize specifically to the male X chromosome. This localization occurs even when roX1 RNAs are expressed from autosomal locations in X-to-autosome translocations. The novel regulation and subnuclear localization of roX1 RNAs makes them candidates for an RNA component of the dosage compensation machinery.

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PubMed Central ID
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Secondary IDs
  • FBrf0092805
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Cell
Title
Cell
Publication Year
1974-
ISBN/ISSN
0092-8674
Data From Reference
Aberrations (2)
Alleles (9)
Genes (9)
Sequence Features (2)
Insertions (1)
Transgenic Constructs (2)