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Citation
Landgraf, M., Roy, S., Prokop, A., VijayRaghavan, K., Bate, M. (1999). even-skipped determines the dorsal growth of motor axons in Drosophila.  Neuron 22(1): 43--52.
FlyBase ID
FBrf0106815
Publication Type
Research paper
Abstract

Axon pathfinding and target choice are governed by cell type-specific responses to external cues. Here, we show that in the Drosophila embryo, motorneurons with targets in the dorsal muscle field express the homeobox gene even-skipped and that this expression is necessary and sufficient to direct motor axons into the dorsal muscle field. Previously, it was shown that motorneurons projecting to ventral targets express the LIM homeobox gene islet, which is sufficient to direct axons to the ventral muscle field. Thus, even-skipped complements the function of islet, and together these two genes constitute a bimodal switch regulating axonal growth and directing motor axons to ventral or to dorsal regions of the muscle field.

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Paper alert.
Anonymous, 1999, Curr. Opin. Neurobiol. 9(2): 144 [FBrf0112205]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (6)
    Genes (10)
    Insertions (1)
    Transgenic Constructs (4)