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Citation
Bello, B.C., Hirth, F., Gould, A.P. (2003). A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis.  Neuron 37(2): 209--219.
FlyBase ID
FBrf0156017
Publication Type
Research paper
Abstract

Postembryonic neuroblasts are stem cell-like precursors that generate most neurons of the adult Drosophila central nervous system (CNS). Their capacity to divide is modulated along the anterior-posterior body axis, but the mechanism underlying this is unclear. We use clonal analysis of identified precursors in the abdomen to show that neuron production stops because the cell death program is activated in the neuroblast while it is still engaged in the cell cycle. A burst of expression of the Hox protein Abdominal-A (AbdA) specifies the time at which apoptosis occurs, thereby determining the final number of progeny that each neuroblast generates. These studies identify a mechanism linking the Hox axial patterning system to neural proliferation, and this involves temporal regulation of precursor cell death rather than the cell cycle.

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Related Publication(s)
Note

Region-specific apoptosis limits neural stem cell proliferation.
Brand and van Roessel, 2003, Neuron 37(2): 185--187 [FBrf0156016]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference