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Citation
Stoleru, D., Peng, Y., Agosto, J., Rosbash, M. (2004). Coupled oscillators control morning and evening locomotor behaviour of Drosophila.  Nature 431(7010): 862--868.
FlyBase ID
FBrf0179740
Publication Type
Research paper
Abstract

Daily rhythms of physiology and behaviour are precisely timed by an endogenous circadian clock. These include separate bouts of morning and evening activity, characteristic of Drosophila melanogaster and many other taxa, including mammals. Whereas multiple oscillators have long been proposed to orchestrate such complex behavioural programmes, their nature and interplay have remained elusive. By using cell-specific ablation, we show that the timing of morning and evening activity in Drosophila derives from two distinct groups of circadian neurons: morning activity from the ventral lateral neurons that express the neuropeptide PDF, and evening activity from another group of cells, including the dorsal lateral neurons. Although the two oscillators can function autonomously, cell-specific rescue experiments with circadian clock mutants indicate that they are functionally coupled.

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Related Publication(s)
Review

Circadian rythms: Sunrise and sunset in fly brains.
Schwartz, 2004, Nature 431(7010): 751--752 [FBrf0179738]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference