Lei, E.P., Corces, V.G. (2006). A long-distance relationship between RNAi and Polycomb.  Cell 124(5): 886--888.

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Note

RNA interference (RNAi) pathways can result in sequence-specific transcriptional gene silencing on the level of chromatin. In this issue of Cell, Grimaud et al. (2006) reveal that the RNAi machinery is required for long-distance physical interactions between chromosomes mediated by the Polycomb repressive complex. These results suggest that the RNAi machinery may regulate higher-order nuclear organization.