Open Close
Reference
Citation
Favrin, G., Bean, D.M., Bilsland, E., Boyer, H., Fischer, B.E., Russell, S., Crowther, D.C., Baylis, H.A., Oliver, S.G., Giannakou, M.E. (2013). Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly.  Sci. Rep. 3(): 3512.
FlyBase ID
FBrf0223654
Publication Type
Research paper
Abstract

The strongest risk factor for developing Alzheimer's Disease (AD) is age. Here, we study the relationship between ageing and AD using a systems biology approach that employs a Drosophila (fruitfly) model of AD in which the flies overexpress the human Aβ42 peptide. We identified 712 genes that are differentially expressed between control and Aβ-expressing flies. We further divided these genes according to how they change over the animal's lifetime and discovered that the AD-related gene expression signature is age-independent. We have identified a number of differentially expressed pathways that are likely to play an important role in the disease, including oxidative stress and innate immunity. In particular, we uncovered two new modifiers of the Aβ phenotype, namely Sod3 and PGRP-SC1b.

PubMed ID
PubMed Central ID
PMC3863820 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference