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Citation
Scott, R.L., Diao, F., Silva, V., Park, S., Luan, H., Ewer, J., White, B.H. (2020). Non-canonical Eclosion Hormone-Expressing Cells Regulate Drosophila Ecdysis.  iScience 23(5): 101108.
FlyBase ID
FBrf0245728
Publication Type
Research paper
Abstract

Eclosion hormone (EH) was originally identified as a brain-derived hormone capable of inducing the behavioral sequences required for molting across insect species. However, its role in this process (called ecdysis) has since been confounded by discrepancies in the effects of genetic and cellular manipulations of EH function in Drosophila. Although knock-out of the Eh gene results in severe ecdysis-associated deficits accompanied by nearly complete larval lethality, ablation of the only neurons known to express EH (i.e. Vm neurons) is only partially lethal and surviving adults emerge, albeit abnormally. Using new tools for sensitively detecting Eh gene expression, we show that EH is more widely expressed than previously thought, both within the nervous system and in somatic tissues, including trachea. Ablating all Eh-expressing cells has effects that closely match those of Eh gene knock-out; developmentally suppressing them severely disrupts eclosion. Our results thus clarify and extend the scope of EH action.

PubMed ID
PubMed Central ID
PMC7225733 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    iScience
    Title
    iScience
    ISBN/ISSN
    2589-0042
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