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General Information
Symbol
GAL4::ER
FlyBase ID
FBto0000136
Name
╬▓estradiol-activated GAL4 driver
Description
Description

The GAL4::ER driver encodes a ligand-inducible transcriptional activator designed for use in a binary expression system. It is composed of the DNA-binding domain from the Saccharomyces cerevisiae GAL4 gene ( SGDID:S000006169 ) fused to the ligand-binding domain from the Homo sapiens estrogen receptor 1 gene (ESR1, HGNC:3467). The GAL4 DNA-binding domain of the GAL4::ER driver can bind specifically to the UAS regulatory sequence, but the presence of the ESR1 ligand-binding domain means that this binding, and subsequent transcriptional activation, can only occur in the presence of estradiol (PMID:3390864).

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Related experimental tools
Transgenic Constructs
Encodes tool (1)
Transgenic construct(s)
Component allele
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Encoded product / tool
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Also carries
Stocks
Insertions ( 8 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
GAL4::ER
Name Synonyms
╬▓estradiol-activated GAL4 driver
Secondary FlyBase IDs
    References (2)