FlyBase Allele Report: Dmel\hth[dtl-S142204]

(Raj et al., 2020, Singh et al., 2011, Link et al., 2007, Kurant et al., 2001, Kurant et al., 1998, Pai et al., 1998, Deak et al., 1997, Jaw et al., 1997, Salzberg et al., 1997, Salzberg et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Salzberg et al., 1997, Salzberg et al., 1997)

lethal - all die before end of larval stage | recessive

(Kurant et al., 1998, Deak et al., 1997)

lethal - all die during embryonic stage | recessive

(Jaw et al., 1997)

some die during embryonic stage | recessive

(Jaw et al., 1997)

some die during larval stage | recessive

(Kurant et al., 1998, Deak et al., 1997)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes die during the second larval instar stage. Homozygous embryos show defects in segmentation and head involution. The LCh5 neurons are located in a more dorsal position than normal in more than 30% of the abdominal segments in homozygous embryos. This phenotype is seen most frequently in abdominal segments A5 to A7. The affected neurons usually remain associated with the dorsal PNS cluster, or occasionally they are positioned between the dorsal and lateral PNS clusters. Those neurons that remain associated with the dorsal PNS cluster have dendrites which point ventrally or posteriorly instead of dorsally. The LCh5 neurons exhibit a DCh3-like morphology in abd-A^D24 hth^dtl-S142204 double mutant embryos and are positioned laterally in 17-19% of abdominal segments.

(Kurant et al., 1998)

Homozygous animals expressing hth^hs.PP are rescued to adulthood in approximately 15% of cases. The rescued adults have a normal head, notum and abdomen, although they have severely shortened legs (similar to the phenotype caused by ectopic expression of hth^hs.PP in a wild-type background).

(Pai et al., 1998)

Homozygotes die as first instar larvae.

(Deak et al., 1997)

Lethality occurs during embryonic and larval stages.

(Salzberg et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hth^dtl-S142204/hth[+] is a suppressor | partially of decreased size | larval stage phenotype of M1BP^HMS02334, Scer\GAL4^ey.PH

(Raj et al., 2020)

hth^dtl-S142204/hth[+] is a suppressor | partially of lethal | pupal stage phenotype of Scer\GAL4^dpp.blk1, tsh^UAS.cGa

(Singh et al., 2002)

hth^dtl-S142204/hth[+] is a suppressor of visible phenotype of Scer\GAL4^dpp.blk1, tsh^UAS.cGa

(Singh et al., 2002)

Other

Statement

Reference

Antp^73b, hth^dtl-S142204, obk¹ has visible phenotype

(Dworkin et al., 2001)

Antp^Ns, hth^dtl-S142204, obk¹ has visible phenotype

(Dworkin et al., 2001)

Phenotype Manifest In

Suppressor of

Statement

Reference

hth^dtl-S142204/hth[+] is a suppressor | partially of eye disc | larval stage phenotype of M1BP^HMS02334, Scer\GAL4^ey.PH

(Raj et al., 2020)

hth^dtl-S142204/hth[+] is a suppressor of eye | somatic clone phenotype of L²

(Singh et al., 2011)

hth^dtl-S142204/hth[+] is a suppressor of eye disc | somatic clone phenotype of L²

(Singh et al., 2011)

hth^dtl-S142204/hth[+] is a suppressor of eye phenotype of Scer\GAL4^dpp.blk1, tsh^UAS.cGa

(Singh et al., 2002)

Other

Statement

Reference

Antp^73b, hth^dtl-S142204, obk¹ has leg | ectopic phenotype

(Dworkin et al., 2001)

Antp^73b, hth^dtl-S142204, obk¹ has antenna phenotype

(Dworkin et al., 2001)

Antp^Ns, hth^dtl-S142204, obk¹ has leg | ectopic phenotype

(Dworkin et al., 2001)

Antp^Ns, hth^dtl-S142204, obk¹ has antenna phenotype

(Dworkin et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The split eye phenotype seen in flies expressing tsh^Scer\UAS.cGa under the control of Scer\GAL4^dpp.blk1 is suppressed by hth^dtl-S142204/+ and pupal lethality is suppressed to 16% (from 42%).

(Singh et al., 2002)

obk¹, Antp^73b (or Antp^Ns), hth^dtl-S142204 triple mutants produce biramous antenna/legs in place of single antennae.

(Dworkin et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

hth^dtl-S142204 is partially rescued by hth^hs.PP

(Pai et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

78355

w^*; P{lacW}hth^dtl-S142204/TM6B, Tb¹

Notes on Origin

Discoverer

Comments

Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

(Salzberg et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

1422-4

(Pai et al., 1998, Jaw et al., 1997)

1422/04

(Deak et al., 1997)

1422/4

(Salzberg et al., 1997)

P1422-4

(Kurant et al., 2001)

dtl^1422-4

dtl¹⁴²²

(Salzberg et al., 1997)

hth^1422-4

(Raj et al., 2020, Singh et al., 2011, Singh et al., 2002, Dworkin et al., 2001)

hth^P1422

(Kurant et al., 1998)

hth^S142204

hth^dtl-1422-4

hth^dtl-1422

hth^dtl-S142204

Name Synonyms

Secondary FlyBase IDs

FBal0060437
FBal0060438

References (12)

Report Sections

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