FlyBase Allele Report: Dmel\lic[G0252]

General Information

Symbol

Dmel\lic^G0252

Species

D. melanogaster

Name

FlyBase ID

FBal0098144

Feature type

allele

Associated gene

Dmel\lic

Associated Insertion(s)

P{lacW}lic^G0252

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schäfer et al., 1999.6.15)

Progenitor genotype

Associated Insertion(s)

P{lacW}lic^G0252

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:13,091,136..13,091,260 [-]

(Schäfer, 2003.12.4, Peter et al., 2002, Schäfer et al., 1999.6.15)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426889

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by Ras85D^V12.cUa.UAS, l(2)gl⁴

(Sun et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal stress response | adult stage

(Hsu et al., 2021)

lethal

(Baril et al., 2009)

partially lethal - majority die | female

(Peter et al., 2002)

partially lethal - majority die | male

(Peter et al., 2002)

partially lethal - majority die | recessive

(Schäfer et al., 1999.6.15)

Phenotype Manifest In

axon | adult stage

(Hsu et al., 2021)

wing nerve

(Hsu et al., 2021)

Detailed Description

Statement

Reference

Only 3% of lic^G0252/Y males reach adulthood.

(Baril et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

lic^G0252 has lethal phenotype, suppressible by alph^S-331/alph^S-331

(Baril et al., 2009)

lic^G0252 has lethal phenotype, suppressible | partially by alph^S-331/alph[+]

(Baril et al., 2009)

lic^G0252 has lethal phenotype, suppressible | partially by alph^XS-88/alph[+]

(Baril et al., 2009)

lic^G0252 has lethal phenotype, suppressible | partially by alph^S-355/alph[+]

(Baril et al., 2009)

lic^G0252 has lethal phenotype, suppressible | partially by alph^c04528/alph[+]

(Baril et al., 2009)

Suppressor of

Statement

Reference

lic^G0252/lic[+] is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

lic^G0252, hep[+], lic[+], hep¹ is a suppressor of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

lic^G0252/lic[+] is a suppressor | partially of neoplasia | somatic clone | larval stage phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴

(Sun et al., 2019)

lic^G0252/lic[+] is a suppressor | partially of abnormal cell migration | somatic clone | larval stage phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴

(Sun et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

lic^G0252, hep[+], lic[+], hep¹ is a suppressor of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

lic^G0252/lic[+] is a suppressor | partially of larval ventral nerve cord | somatic clone | larval stage phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴

(Sun et al., 2019)

lic^G0252/lic[+] is a suppressor | partially of eye disc | somatic clone phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴

(Sun et al., 2019)

lic^G0252/lic[+] is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Introduction of a homozygous alph^S-331 allele into the lic^G0252 background strongly suppresses hemizygous male lethality.

Introduction of a heterozygous alph^S-331, alph^XS-88, alph^S-355, or alph^c04528 allele into the lic^G0252 background suppresses hemizygous male lethality.

(Baril et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.6.15)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426889

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

l(1)G0252

(Schäfer, 2003.12.4, Peter et al., 2002)

l(1)G0252^G0252

(Schäfer et al., 1999.6.15)

lic^G0252

(Hsu et al., 2021, Sun et al., 2019, Popodi et al., 2010-, Baril et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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