FlyBase Allele Report: Dmel\Diap1[6B]

General Information

Symbol

Dmel\Diap1^6B

Species

D. melanogaster

Name

FlyBase ID

FBal0103511

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

Also Known As

th^6B

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Rodriguez et al., 2002, Lisi et al., 2000)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: C412Y. The mutation is within the RING domain.

(Rodriguez et al., 2002)

Amino acid replacement: C412Y. C412 falls in the RING domain.

(Lisi et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,038,754..16,038,754 [-]

Nucleotide change:

G16038754A

Amino acid change:

Reported amino acid change:

C412Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. C412 falls in the RING domain.

(Lisi et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with Diap1⁸)

(Rodriguez et al., 2002)

lethal | recessive

(Lisi et al., 2000)

viable (with Diap1^21-2s)

(Geisbrecht and Montell, 2004)

Phenotype Manifest In

egg chamber (with Diap1⁸)

(Rodriguez et al., 2002)

egg chamber (with Diap1^21-2s)

(Geisbrecht and Montell, 2004)

nurse cell | increased number (with Diap1^21-2s)

(Geisbrecht and Montell, 2004)

ovariole (with Diap1⁸)

(Xu et al., 2005)

ovary (with Diap1⁸)

(Rodriguez et al., 2002)

Detailed Description

Statement

Reference

The ovarioles are poorly developed and atrophied in th⁸/th^6B females.

(Xu et al., 2005)

Less than 1% of th^6B/th^21-2s egg chambers have border follicle cell migration defects, while 10% have more than 15 nurse cells. 10% of th^6B/th^21-2s egg chambers show polarity defects. Homozygous follicle cells clones do not result in border follicle cell migration defects.

(Geisbrecht and Montell, 2004)

91% of th^6B/th⁸ females fail to lay eggs. Females have severely stunted and irregularly shaped ovaries that appear atrophied. Most egg chambers exhibit overtly degenerative phenotypes.

(Rodriguez et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Diap1^6B/Diap1⁸ has female sterile phenotype, suppressible | partially by Dark^CD4

(Rodriguez et al., 2002)

Enhancer of

Statement

Reference

Diap1^6B is an enhancer of abnormal cell death phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Diap1^6B is an enhancer of abnormal cell death phenotype of grim^GMR.PC

(Lisi et al., 2000)

Suppressor of

Statement

Reference

th[+]/Diap1^6B is a suppressor of visible | somatic clone phenotype of Uba1^A1

(Pfleger et al., 2007)

Diap1^6B is a suppressor of abnormal cell death phenotype of hid^GMR.PG

(Lisi et al., 2000)

Diap1^6B is a suppressor of viable phenotype of hid^hs.PG

(Lisi et al., 2000)

Diap1^6B is a suppressor of abnormal cell death phenotype of hid^hs.PG

(Lisi et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

Diap1^6B/Diap1⁸ has ovariole phenotype, suppressible | partially by Dronc^I24/Dronc^L32

(Xu et al., 2005)

Diap1^6B/Diap1⁸ has egg chamber phenotype, suppressible | partially by Dark^CD4

(Rodriguez et al., 2002)

Diap1^6B/Diap1⁸ has ovary phenotype, suppressible | partially by Dark^CD4

(Rodriguez et al., 2002)

Enhancer of

Statement

Reference

Diap1^6B is an enhancer of eye phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Diap1^6B is an enhancer of eye phenotype of grim^GMR.PC

(Lisi et al., 2000)

Suppressor of

Statement

Reference

th[+]/Diap1^6B is a suppressor of eye | somatic clone phenotype of Uba1^A1

(Pfleger et al., 2007)

Diap1^6B is a suppressor of embryo phenotype of hid^hs.PG

(Lisi et al., 2000)

Diap1^6B is a suppressor of adult phenotype of hid^hs.PG

(Lisi et al., 2000)

Diap1^6B is a suppressor of eye phenotype of hid^GMR.PG

(Lisi et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The overgrowth phenotype that is caused by homozygous clones in the eye is enhanced by Df(3L)H99/+ and is suppressed by th^6B/+.

(Pfleger et al., 2007)

The Nc^I24/Nc^L32 combination partially suppresses the ovarian atrophy phenotype seen in th⁸/th^6B mutants; the egg chamber is significantly enlarged compared to the th⁸/th^6B mutant.

(Xu et al., 2005)

The addition of Ark^CD4/Ark^CD4 or Ark^CD4/+ to suppresses the sterility of th^6B/th⁸ females, leading to 47% and 69% of females laying eggs respectively. Ovaries are considerably larger and generally wild-type in appearance. Most egg chambers are normal in morphology and number.

(Rodriguez et al., 2002)

Increases the viability of W^hs.PG flies threefold.

(Lisi et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

600370

Diap1^6B/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Diap1⁶

(Rodriguez et al., 2002)

Diap1^6B

diap1^6B

(Xu et al., 2005)

th^6B

(Guan et al., 2007, Pfleger et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close

General Information
Nature of the Allele
Expression Data
Human Disease Associations
Phenotypic Data
Interactions
Complementation and Rescue Data
Images
Stocks
Notes On Origin
Crossreferences
Synonyms and Secondary IDs
References