FB2025_01 , released February 20, 2025
Gene Group: HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES
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General Information
Name
HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES
Species
D. melanogaster
Symbol
HSP40
FlyBase ID
FBgg0000504
Date last reviewed
2024-09-18
Number of members
42
Description
Description
The Heat Shock Protein 40 (Hsp40) family of co-chaperones are essential factors in the Hsp70 chaperone cycle. The Hsp40 family is diverse in size and structure, but a number of them are about 40kDa and have been identified as products of heat shock genes. Their defining feature is the DnaJ or J-domain corresponding to the N-terminal 70 amino acids of the Escherichia coli co-chaperone DnaJ. (Adapted from FBrf0173155).
Notes on Group

The gene products of blp and CG1409 have been excluded from the HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES gene group as they lack the functionally important HPD motif of the DnaJ domain(FBrf0134627). blp and CG1409 are Pam16 family proteins, subunits of the mitochondrial presequence translocase-associated motor (PAM) subcomplex of the TIM23 complex.

Source Material
The HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES Gene Group has been compiled using the following publication(s): Deo et al., 2024, Li et al., 2016, and Ratheesh et al., 2012 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
HEAT SHOCK PROTEINS
Members (42)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
aux
auxilin
auxillin, dAux
(Ratheesh et al., 2012)
CG2790
(Ratheesh et al., 2012)
CG2887
(Deo et al., 2024, Ratheesh et al., 2012)
CG3061
(Deo et al., 2024, Ratheesh et al., 2012)
CG5001
(Deo et al., 2024, Ratheesh et al., 2012)
CG5504
l(2)tid, lethal (2) tumorous imaginal discs, lethal(2) tumorous imaginal discs, lethal(2)tumorous imaginal discs, DnaJ
(Ratheesh et al., 2012)
CG6693
(Deo et al., 2024, Ratheesh et al., 2012)
CG7130
(Deo et al., 2024, Ratheesh et al., 2012)
CG7133
(Deo et al., 2024, Ratheesh et al., 2012)
CG7387
(Deo et al., 2024, Ratheesh et al., 2012)
CG7394
(Deo et al., 2024, Ratheesh et al., 2012)
CG7556
(Deo et al., 2024, Ratheesh et al., 2012)
CG7872
(Deo et al., 2024, Ratheesh et al., 2012)
CG8476
(Deo et al., 2024, Ratheesh et al., 2012)
CG8531
(Deo et al., 2024, Ratheesh et al., 2012)
CG10375
(Deo et al., 2024, Ratheesh et al., 2012)
CG10565
(Deo et al., 2024, Ratheesh et al., 2012)
CG11035
(Deo et al., 2024, Ratheesh et al., 2012)
CG12020
(Deo et al., 2024, Ratheesh et al., 2012)
CG14650
(Deo et al., 2024, Ratheesh et al., 2012)
CG17187
(Deo et al., 2024, Ratheesh et al., 2012)
CG30156
(Deo et al., 2024, Ratheesh et al., 2012)
CG32640
(Ratheesh et al., 2012)
CG32641
(Deo et al., 2024, Ratheesh et al., 2012)
CG32727
anon-SAGE:Wang-041
(Ratheesh et al., 2012)
CG43322
(Deo et al., 2024, Ratheesh et al., 2012)
Csp
Cysteine string protein
cystein string protein, l(3)03988, Dcsp, ab49
(Deo et al., 2024, Ratheesh et al., 2012)
DnaJ-1
DnaJ-like-1
Hsp40, dHDJ1, Hdj1, DnaJ1, droj1
(Deo et al., 2024, Li et al., 2016, Ratheesh et al., 2012)
DnaJ-60
DnaJ-like-60
DnaJ60
(Deo et al., 2024, Ratheesh et al., 2012)
DnaJ-H
DnaJ homolog
(Deo et al., 2024, Ratheesh et al., 2012)
Dph4
Diphthamide biosynthesis 4
(Deo et al., 2024)
Droj2
DnaJ-like-2
(Deo et al., 2024, Li et al., 2016, Ratheesh et al., 2012)
Hsc20
Heat shock protein cognate 20
l(3)72Do
(Deo et al., 2024, Ratheesh et al., 2012)
jdp
jdp
dJDP
(Deo et al., 2024, Ratheesh et al., 2012)
l(3)80Fg
lethal (3) 80Fg
l4A, l(3)Lh4A
(Ratheesh et al., 2012)
mrj
mrj
dMRJ
(Deo et al., 2024, Li et al., 2016, Ratheesh et al., 2012)
P58IPK
P58IPK
(Deo et al., 2024, Ratheesh et al., 2012)
Rme-8
Receptor mediated endocytosis 8
l(2)45Ba
(Ratheesh et al., 2012)
Sec63
Secretory 63
(Deo et al., 2024, Ratheesh et al., 2012)
shv
shriveled
(Deo et al., 2024, Ratheesh et al., 2012)
Tpr2
Tetratricopeptide repeat protein 2
dTPR2, Trp2
(Deo et al., 2024, Ratheesh et al., 2012)
wus
wurst
(Deo et al., 2024, Ratheesh et al., 2012)
External Data
Equivalent Group(s)
Other resource(s)

[Heat shock protein information resource:Hsp40 ](http://pdslab.biochem.iisc.ernet.in/hspir/hsp40.php)

Synonyms and Secondary IDs
Synonym(s)
HSP40
HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES
DnaJ heat shock proteins
J-proteins
DnaJ domain proteins
Heat shock proteins 40kDa
DnaJ
Secondary FlyBase ID(s)
References (4)