FB2025_01 , released February 20, 2025
Gene: Zzzz\VHH
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General Information
Symbol
Zzzz\VHH
Species
a. artificial
Name
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0287853
Gene Model Status
Not Applicable
Stock Availability
56 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Foreign Gene Data

An engineered antibody ('nanobody') consisting of the antigen-binding variable domain (VHH domain) of a camelid single-domain heavy chain antibody (HCab).

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 86 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Zzzz\VHH
Transgenic constructs containing regulatory region of Zzzz\VHH
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | heat sensitive, with Scer\GAL4da.PU, brpMI02987-GFSTF.0
lethal | heat sensitive, with Scer\GAL4nSyb.PS, brpMI02987-GFSTF.0
lethal - all die during embryonic stage | heat sensitive, with Scer\GAL4Tub.PU, dlg1MI06353-GFSTF.0
lethal - all die during embryonic stage | heat sensitive, with α-CatMI02577-GFSTF.0, Scer\GAL4Act.PU
viable, with Scer\GAL4nullo.PG
viable, with Scer\GAL4Tub.PU
Sterility
Allele
fertile, with Nrx-120xUAS.Tag:ALFA, Scer\GAL4Nrx-1-MI10278-TG4.1
fertile, with Scer\GAL4nullo.PG
fertile, with Scer\GAL4Tub.PU
Other Phenotypes
Allele
abnormal developmental rate | gastrula stage, with cherCPTI001399
abnormal learning | heat sensitive, with Pde4MI03415-GFSTF.2, Scer\GAL4117Y
abnormal locomotor behavior | adult stage, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4Act5C.PI
abnormal locomotor behavior | adult stage | progressive, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4Act5C.PI
abnormal locomotor behavior | adult stage | progressive, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4nSyb.PS
abnormal locomotor behavior | heat sensitive, with Scer\GAL4nSyb.PS, brpMI02987-GFSTF.0
abnormal memory | conditional, with Scer\GAL4Mef2.247, mengMI03008-GFSTF.1
abnormal mitotic cell cycle | embryonic stage, with Mms19EGFP, Mms19EY00797
abnormal neuroanatomy | adult stage | progressive, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4nSyb.PS
abnormal neurophysiology, with Scer\GAL4ey.PU, brpMI02987-GFSTF.0
abnormal neurophysiology | heat sensitive, with Scer\GAL4nSyb.PS, brpMI02987-GFSTF.0
abnormal planar polarity, with Rab23EYFP, Scer\GAL4en.PU
abnormal size | adult stage, with Ecol\lexALG.dpp, dppd12/dppd8, dpplexAop.cHa.EGFP
abnormal size | adult stage, with Ecol\lexALG.dpp, Scer\GAL4hh.PU, dppd12/dppd8, dpplexAop.cHa.EGFP
abnormal size | third instar larval stage, with Ecol\lexALG.dpp, dppd12/dppd8, dpplexAop.cHa.EGFP
abnormal size | third instar larval stage, with Ecol\lexALG.dpp, Scer\GAL4hh.PU, dppd12/dppd8, dpplexAop.cHa.EGFP
short lived, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4Act5C.PI
short lived, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4nSyb.PS
visible, with α-CatMI02577-GFSTF.0, Scer\GAL4ey.PU
visible | adult stage, with Ecol\lexALG.dpp, dppd12/dppd8, dpplexAop.cHa.EGFP
visible | adult stage, with Ecol\lexALG.dpp, Scer\GAL4hh.PU, dppd12/dppd8, dpplexAop.cHa.EGFP
Phenotype manifest in
Allele
actomyosin contractile ring | embryonic stage 5, with cherCPTI001399
actomyosin contractile ring | embryonic stage 5, with FimCPTI100066
axon | adult stage | decreased number, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4Act5C.PI
axon | adult stage | decreased number, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4nSyb.PS
centrosome | embryonic stage, with Mms19EGFP, Mms19EY00797
chromosome | embryonic stage, with Mms19EGFP, Mms19EY00797
embryo, with Rab8EGFP, Scer\GAL4VP16.mat.αTub67C
embryonic/larval midgut | heat sensitive, with Scer\GAL4Tub.PU, dlg1MI06353-GFSTF.0
embryonic/larval neuromuscular junction | heat sensitive, with Scer\GAL4Tub.PU, dlg1MI06353-GFSTF.0
embryonic epidermis | embryonic stage 5, with cherCPTI001399
embryonic epidermis | embryonic stage 5, with FimCPTI100066
eye, with α-CatMI02577-GFSTF.0, Scer\GAL4ey.PU
filamentous actin | embryonic stage 5, with cherCPTI001399
filamentous actin | embryonic stage 5, with FimCPTI100066
larval brain | heat sensitive, with Scer\GAL4Tub.PU, dlg1MI06353-GFSTF.0
marginal nerve, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4Act5C.PI
marginal nerve, with PitsMI02926-DH.PT-GFSTF.1, Scer\GAL4nSyb.PS
mitotic spindle | embryonic stage, with Mms19EGFP, Mms19EY00797
synaptonemal complex | conditional, with Scer\GAL4nanos.PG, vtdαTub84B.EGFP, vtdex3
wing blade, with Ecol\lexALG.dpp, dppd12/dppd8, dpplexAop.cHa.EGFP
wing blade, with Ecol\lexALG.dpp, Scer\GAL4hh.PU, dppd12/dppd8, dpplexAop.cHa.EGFP
wing disc | heat sensitive, with Scer\GAL4Tub.PU, dlg1MI06353-GFSTF.0
wing disc | third instar larval stage, with Ecol\lexALG.dpp, dppd12/dppd8, dpplexAop.cHa.EGFP
wing disc | third instar larval stage, with Ecol\lexALG.dpp, Scer\GAL4hh.PU, dppd12/dppd8, dpplexAop.cHa.EGFP
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Summary of Genetic Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Other Comments
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    VHH
    Zzzz\VHH
    Name Synonyms
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 0 )
      References (47)