Reference Report

Reference
Citation	Usui-Aoki, K., Ito, H., Ui-Tei, K., Takahashi, K., Lukacsovich, T., Awano, W., Nakata, H., Piao, Z.F., Nilsson, E.E., Tomida, J., Yamamoto, D. (2000). Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat. Cell Biol. 2(8): 500--506. (Export to RIS)
FlyBase ID	FBrf0130128
Publication Type	Research paper
PubMed ID	10934470
PubMed Abstract	The Drosophila fruitless (fru) gene product Fru has been postulated to be a neural sex-determination factor that directs the development of at least two male-specific characteristics, namely courtship behaviour and formation of the muscle of Lawrence (MOL). The fru gene encodes a putative transcription factor with a BTB domain and two zinc-finger motifs, and with consensus Tra-binding sequences. The binding of Tra to these sequences results in sex-specific alternative splicing of the fru mRNA, leading to production of the 'male-type' or 'female-type' Fru protein. We show here that the Fru protein is not detected in the female central nervous system (CNS), despite the similar level of expression of fru mRNA in both male and female CNS. As ectopic expression of both the 'male-type' (with the sequence for the amino-terminal extension) and 'female-type' (without the sequence for the amino-terminal extension) fru cDNA can induce formation of the MOL in females, the presence or absence of the Fru protein, and not its sex-specific structure, seems to be responsible for the sexually dimorphic actions of the fru gene.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Cell Biol.
Title	Nature Cell Biology
Publication Year	1999-
ISBN/ISSN	1465-7392 1476-4679
Data from Reference
Alleles (23)
	fru^A.hs fru^{A.Scer\UAS.cUa} fru^AM.hs fru^{AM.Scer\UAS.cUa} fru^B.hs fru^{B.Scer\UAS.cUa} fru^{BM.Scer\UAS.cUa} fru^C.hs fru^{C.Scer\UAS.cUa} fru^D.hs fru^{D.Scer\UAS.cUa} fru^E.hs fru^{E.Scer\UAS.cUa} fru^{EM.Scer\UAS.cUa} fru^sat Ppyr\LUC^fru.TraB Ppyr\LUC^hs.PU Scer\GAL4^D42 Scer\GAL4^GMR.PF tra2^hs.PH tra¹ tra^hs.PH w^+mC
Constructs (15)
	P{GAL4-ninaE.GMR} P{hs-fru.A} P{hs-fru.AM} P{hs-fru.B} P{hs-fru.C} P{hs-fru.D} P{hs-fru.E} P{UAS-fru.A.U} P{UAS-fru.AM.U} P{UAS-fru.B.U} P{UAS-fru.BM.U} P{UAS-fru.C.U} P{UAS-fru.D.U} P{UAS-fru.E.U} P{UAS-fru.EM.U}
Genes (8)
	elav fru futsch Ppyr\LUC Scer\GAL4 tra tra2 w
Insertions (2)
	P{GawB}D42 P{lwB}fru^sat