FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ash111
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General Information
Symbol
Dmel\ash111
Species
D. melanogaster
Name
FlyBase ID
FBal0000741
Feature type
allele
Associated gene
Dmel\ash1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Tripoulas et al., 1996)
Mutagen
gamma ray
(Tripoulas et al., 1996, Tripoulas et al., 1994)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C4759A.

(Tripoulas et al., 1996)

Amino acid replacement: S1248term.

(Tripoulas et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,594,435..19,594,435 [-]
Nucleotide change:

C19594435A

Reported nucleotide change:

T7127A

Amino acid change:

S1247term | ash1-PB; S1247term | ash1-PC

Reported amino acid change:

S1248term

(Tripoulas et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ash111/Df(3L)kto2 lethality occurs at the end of the third larval instar or just after puparium formation.

      (Tripoulas et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ash111 is a suppressor | partially of wing phenotype of Scer\GAL4OK386, nejUAS.cMa

      (Bantignies et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double heterozygotes with Ubxabx-1, trxel2 or brm2 exhibit transformation of third leg to second leg identity and haltere to wing transformation.

      (Tripoulas et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

      (Tripoulas et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      TK117
      ash111
      (Tripoulas et al., 1996)
      dash3
      (Lindsley and Zimm, 1992)
      dashGTK117
      (Shearn et al., 1971)
      γTK117
      Name Synonyms
      Secondary FlyBase IDs
        References (5)