FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ex1
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General Information
Symbol
Dmel\ex1
Species
D. melanogaster
Name
FlyBase ID
FBal0003906
Feature type
allele
Associated gene
Dmel\ex
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ex1 homozygous mutant embryos display a significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage.

      (Keder et al., 2015)

      Broad wing phenotype. Mutant wings have undergone at least one extra cell division.

      (Boedigheimer and Laughon, 1993)

      Effect produced in prepupal wing, probably by influence on cell division.

      (Waddington, 1940)

      Wings extremely wide and large, sometimes curved and divergent. Eyes slightly reduced in size and roughish. Body large. RK2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      ex1/ex[+] is a non-enhancer of visible | adult stage phenotype of MagiUAS.GFP, Scer\GAL4GMR.PU

      (Zaessinger et al., 2015)
      NOT Suppressor of
      Statement
      Reference

      ex1/ex[+] is a non-suppressor of visible | adult stage phenotype of MagiUAS.GFP, Scer\GAL4GMR.PU

      (Zaessinger et al., 2015)
      Other
      Statement
      Reference

      cno2, ex1/ex[+] has abnormal neuroanatomy | embryonic stage phenotype

      (Keder et al., 2015)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      ex1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      NOT Enhancer of
      Statement
      Reference

      ex1/ex[+] is a non-enhancer of eye | adult stage phenotype of MagiUAS.GFP, Scer\GAL4GMR.PU

      (Zaessinger et al., 2015)
      NOT Suppressor of
      Statement
      Reference

      ex1/ex[+] is a non-suppressor of eye | adult stage phenotype of MagiUAS.GFP, Scer\GAL4GMR.PU

      (Zaessinger et al., 2015)
      Other
      Statement
      Reference

      cno2, ex1/ex[+] has larval RP2 motor neuron | embryonic stage phenotype

      (Keder et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in cno2/+;ex1/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

      (Keder et al., 2015)

      The rough eye phenotype observed in adults expressing MagiScer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PU is not modified by combination with single copy of ex1.

      (Zaessinger et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      exk12913

      (Lee et al., 2008)
      Fails to complement

      exNY1

      (Tyler et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (7)
      Notes on Origin
      Discoverer

      Bridges, 21st Nov. 1917.

      Comments
      Comments

      An allelic series can be defined for ex alleles with respect to viability, eclosion rate and penetrance of ex wing phenotype. Going from most to least severe: exe1 >= exl2ey > exe2 > exe6 > ex697 > ex1.

      (Boedigheimer and Laughon, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (11)