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General Information
Symbol
Dmel\Gpdh1n1-4
Species
D. melanogaster
Name
FlyBase ID
FBal0005144
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
n1-4
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G5946338A

Reported nucleotide change:

G?A

Amino acid change:

G151D | Gpdh-PA; G151D | Gpdh-PB; G151D | Gpdh-PC; G151D | Gpdh-PE; G151D | Gpdh-PF; G151D | Gpdh-PG

Reported amino acid change:

G151D

Comment:

Reported as Gly to Asn, GGC to GAC. Amino acid change presumed to be a typo. Should be Gly to Asp.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies do not show significantly increased survival compared to wild-type flies after infection with E. chaffeensis.

Adults are visibly normal but cannot sustain flight.

%CRM by rocket electrophoresis: >5 % wildtype enzyme activity: 1 relative enzyme mobility: >GpdhB relative viability: .20 flightless

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Gpdhn1-4 enhances the curled or crumpled wing phenotype seen in Scer\GAL4c564>Gk1dsRNA.Scer\UAS-let escapers.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

S.J. O'Brien.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Gpdh1n1-4
GpdhB0-1-4
α-GPDH-1N1-4
Name Synonyms
negative 1-4
Secondary FlyBase IDs
    References (8)