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General Information
Symbol
Dmel\hb7
Species
D. melanogaster
Name
FlyBase ID
FBal0005398
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hb9K57
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G8692694A

Reported nucleotide change:

G?A

Amino acid change:

W487term | hb-PA; W487term | hb-PB

Reported amino acid change:

W487term

Comment:

TGG to TGA

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation in the region between the first two zinc fingers, the D box.

Nucleotide substitution: G?A.

Amino acid replacement: W487term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

An amorphic allele exhibiting loss of zygotic hb function with an antimorphic effect with respect to maternal hb function.

Homozygotes and heterozygotes with a wild type copy display a severely reduced head, up to three abdominal segments are formed in the head region.

Lacks gnathal and thoracic segments. Irregular shape denticle bands are formed from anterior to posterior abdomen, are of correct polarity.

Homozygous embryos lack labium and all thoracic segments; head and gnathal segments transformed into posterior abdominal segments as is A1. Expressed only in homozygotes, not in hemizygotes; hb7 hemizygotes displays class III phenotype. Lethality of hb7 homozygotes not rescued by Dp(3;Y)P92 which is able to cover the other alleles; attempts to implicate a linked lethal mutation negative.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Class V allele.

Phenotypic class Vb hb allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (10)