FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\snRNP-U1-70K02107
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General Information
Symbol
Dmel\snRNP-U1-70K02107
Species
D. melanogaster
Name
FlyBase ID
FBal0007994
Feature type
allele
Associated gene
Dmel\snRNP-U1-70K
Associated Insertion(s)
P{PZ}snRNP-U1-70K02107
Carried in Construct
Also Known As
U1-70K1, l(2)02107, snRNPU1-70K02107
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Tseng et al., 1998)
Progenitor genotype
Associated Insertion(s)
P{PZ}snRNP-U1-70K02107
Cytology
Description

Insertion in the 5' UTR.

(Salz et al., 2004)

The P{PZ} insertion is 115bp upstream of the translation start site of snRNP70K.

(Cline et al., 1999)

P-element insertion in the 5' untranslated region.

(Tseng et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes complete embryogenesis with no consistent cuticular phenotype, but never hatch.

      (Salz et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Other
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When mothers heterozygous for both snfJ210 and snRNP70K02107 are crossed with SxlfP7B0 males, a significant reduction in viability is seen in SxlfP7B0/+ daughters. When mothers heterozygous for both snfJ210 and snRNP70K02107 are crossed with SxlfP7B0 males, a significant reduction in viability is seen in SxlfP7B0/+ daughters.

      (Nagengast et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference

      The addition of snRNP70K::Hsap\SFRS1T:Zzzz\FLAG rescues the snRNP70K02107 phenotype.

      (Cline et al., 1999)
      Complementation and Rescue Data
      Fails to complement

      snRNP-U1-70K2

      (Salz et al., 2004)
      Rescued by

      snRNP-U1-70K02107 is rescued by snRNP-U1-70Khs.PS

      (Salz et al., 2004)

      snRNP-U1-70K02107 is rescued by snRNP-U1-70K+t9

      (Salz et al., 2004)
      Comments

      A transgene construct lacking the arginine-rich domain also rescues the lethality.

      (Tseng et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Excision of the P-element restores viability, as do transgenes carrying either a wildtype genomic fragment or cDNA under the control of the Hsp70 promoter. Some partial revertants show partial female-specific lethality and defects in oogenesis.

      (Tseng et al., 1998)

      "FBti0005210 == FBti0000289 == P{PZ}snRNP70K02107" was stated as revision.

      (Mount, 1999.5.23)

      Complements: Hrb27C02647. Complements: smt304493. Complements: smt304841. Complements: Hrb27C10280. Complements: smt310636. Complements: miltk06704. Complements: Coproxk10617. Complements: miltk14514b. Complements: cuc06491.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (11)
      Reported As
      Symbol Synonym
      70K1
      (Mount, 1999.5.23, Tseng et al., 1998)
      U1-70K02107
      (Blanco et al., 2025)
      U1-70K1
      (Salz et al., 2004, Nagengast et al., 2003, Cline et al., 1999)
      U1-70k1
      (Penn et al., 2008)
      l(2)02107
      (Salz et al., 2004, Spradling et al., 1999)
      l(2)0210702107
      (Mount, 1999.5.23)
      snRNP-U1-70K02107
      snRNP27D02107
      snRNP27D1
      snRNP70K02107
      (Sofola et al., 2007)
      snRNPU1-70K02107
      (Blanco et al., 2025, Carnesecchi et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0086333
      References (13)