FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CadNM12
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General Information
Symbol
Dmel\CadNM12
Species
D. melanogaster
Name
FlyBase ID
FBal0008574
Feature type
allele
Associated gene
Dmel\CadN
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Iwai et al., 1997)
Mutagen
spontaneous
Progenitor genotype
Cytology
Description

Amino acid replacement: E1425K. Nucleotide substitution: G?A.

(Iwai et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:17,668,039..17,668,039 [-]
Nucleotide change:

G17668039A

Reported nucleotide change:

G?A

Amino acid change:

E1420K | CadN-PA; E1420K | CadN-PB; E1420K | CadN-PC; E1420K | CadN-PD; E1420K | CadN-PE; E1420K | CadN-PF; E1420K | CadN-PG; E1420K | CadN-PH; E1424K | CadN-PI; E1424K | CadN-PJ; E1424K | CadN-PK; E1424K | CadN-PL

Reported amino acid change:

E1425K

(Iwai et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CadNM12/+ mutants display significantly decreased numbers of hub cells, germline stem cells and cyst stem cells in the testicular niche.

      (Lim et al., 2015)

      Adults exhibit strongly uncoordinated or reduced locomotion.

      (Iwai et al., 1997)

      larval lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      CadNM12 is a non-suppressor of lethal | pupal stage phenotype of Cskj1D8/CskS030003

      (Read et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When small clones of cells homozygous for shgR69 are present in the retina of CadNM19/CadNM12 pupae (40 hours after puparium formation), cone cells in the mutant clones fail to adhere to their cone cell or primary pigment cell neighbours, and some lose all apical contact with other cells. The mutant cells round up, and the remaining wild-type cone cells in mosaic ommatidia pack into configurations typical for soap bubble aggregates.

      (Hayashi and Carthew, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Bridges.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      Reported As
      Symbol Synonym
      CadN1
      CadNM12
      N-Cadunprocessable
      (Lim et al., 2015)
      NCadM12
      (Lim et al., 2015)
      l(2)36Da1
      l(2)36DaM12
      (Iwai et al., 1997)
      l(2)Bld
      n-cadM12
      (Seppa et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)