FlyBase Allele Report: Dmel\mub[04093]

General Information

Symbol

Dmel\mub⁰⁴⁰⁹³

Species

D. melanogaster

Name

FlyBase ID

FBal0009504

Feature type

allele

Associated gene

Dmel\mub

Associated Insertion(s)

P{PZ}mub⁰⁴⁰⁹³

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}mub⁰⁴⁰⁹³

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:21,880,058..21,880,058 [+]

(Branco et al., 2008, Fernandez-Funez et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eclosion (with Df(3L)Exel6137)

(Geng and MacDonald, 2007)

abnormal locomotor behavior (with Df(3L)Exel6137)

(Geng and MacDonald, 2007)

flightless (with Df(3L)Exel6137)

(Geng and MacDonald, 2007)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

No retinal phenotypes are seen in mub⁰⁴⁰⁹³ mutant flies.

(Branco et al., 2008)

mub⁰⁴⁰⁹³ flies, in trans to Df(3L)Exel6137 flies very rarely eclose. Those that do exhibit defective locomotive behaviour (they are flightless and stick to the growth medium) and die within several days. The few eggs that are laid from these flies are phenotypically normal.

Flies with mub⁰⁴⁰⁹³ in trans to Df(3L)ED4978 (which leaves the mub coding region intact but deletes part of the first mub intron, all of the first mub exon, and all 5' flanking sequences) can eclose, although at a low frequency. They exhibit locomotive defects and live for up to 7 days. The few eggs that are laid from these flies are phenotypically normal.

(Geng and MacDonald, 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mub⁰⁴⁰⁹³/mub[+] is an enhancer of visible | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

NOT Enhancer of

Statement

Reference

mub⁰⁴⁰⁹³ is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

NOT Suppressor of

Statement

Reference

mub⁰⁴⁰⁹³ is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

mub⁰⁴⁰⁹³ has eye phenotype, non-enhanceable by Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

mub⁰⁴⁰⁹³ has retina phenotype, non-enhanceable by Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT suppressed by

Statement

Reference

mub⁰⁴⁰⁹³ has eye phenotype, non-suppressible by Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

mub⁰⁴⁰⁹³ has retina phenotype, non-suppressible by Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Enhancer of

Statement

Reference

mub⁰⁴⁰⁹³/mub[+] is an enhancer of ommatidium phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

mub⁰⁴⁰⁹³/mub[+] is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

mub⁰⁴⁰⁹³/mub[+] is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

mub⁰⁴⁰⁹³/mub[+] is an enhancer of egg phenotype of Imp^UAS.cGa, Scer\GAL4^{VP16.mat.αTub67C}

(Geng and MacDonald, 2007)

mub⁰⁴⁰⁹³/mub[+] is an enhancer of egg chorion phenotype of Imp^UAS.cGa, Scer\GAL4^{VP16.mat.αTub67C}

(Geng and MacDonald, 2007)

NOT Enhancer of

Statement

Reference

mub⁰⁴⁰⁹³/mub[+] is a non-enhancer of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

mub⁰⁴⁰⁹³/mub[+] is a non-enhancer of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

mub⁰⁴⁰⁹³ is a non-enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

mub⁰⁴⁰⁹³ is a non-enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Suppressor of

Statement

Reference

mub⁰⁴⁰⁹³/mub[+] is a non-suppressor of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

mub⁰⁴⁰⁹³ is a non-suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

mub⁰⁴⁰⁹³ is a non-suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

A heterozygous mub⁰⁴⁰⁹³ background moderately enhances the dorsalisation phenotype seen when Imp^Scer\UAS.cGa is expressed under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} (on the second).

(Geng and MacDonald, 2007)

Xenogenetic Interactions

Statement

Reference

One copy of mub⁰⁴⁰⁹³ does not enhance the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of mub⁰⁴⁰⁹³ enhances the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Branco et al., 2008)

Complementation and Rescue Data

Fails to complement

mub^j8B3

(BDGP Project Members, 1994-1999)

mub^j6B10

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11624

P{PZ}mub⁰⁴⁰⁹³ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: l(3)00836⁰⁰⁸³⁶.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Mub⁰⁴⁰⁹³

(Christensen et al., 2007.5.8)

l(3)04093

(Spradling et al., 1999)

l(3)04093⁰⁴⁰⁹³

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

mub⁰¹⁰³⁸

(Mutsuddi et al., 2004)

mub⁰⁴⁰⁹³

(Branco et al., 2008, Cao et al., 2008, Geng and MacDonald, 2007)

mub⁰⁴⁹⁰⁹³

(Fernandez-Funez et al., 2000)

mub^LOF

(Branco et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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