FlyBase Allele Report: Dmel\bnl[06916]

General Information

Symbol

Dmel\bnl⁰⁶⁹¹⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0009582

Feature type

allele

Associated gene

Dmel\bnl

Associated Insertion(s)

P{PZ}bnl⁰⁶⁹¹⁶

Carried in Construct

Also Known As

bnl-lacZ, bnl^P2

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Sutherland et al., 1996)

Mutagen

P-element activity

(Sutherland et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{PZ}bnl⁰⁶⁹¹⁶

Cytology

Description

P{PZ} insertion lies about 8kb upstream of the cDNA.

(Sutherland et al., 1996)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:19,836,868..19,836,868 [+]

(Yan and Lin, 2007, Park et al., 2003, Spradling et al., 1999, Sutherland et al., 1996, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | larval stage

(Destalminil-Letourneau et al., 2021)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

embryonic/larval crystal cell | increased number | larval stage

(Destalminil-Letourneau et al., 2021)

larval tracheal system

(Sutherland et al., 1996)

Detailed Description

Statement

Reference

bnl⁰⁶⁹¹⁶/+ larvae have normal numbers S phase neuroblasts per brain lobe.

(Park et al., 2003)

Sporadic defects in primary, secondary and terminal branch formation and outgrowth.

(Sutherland et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

bnl⁰⁶⁹¹⁶/bnl[+] is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

bnl⁰⁶⁹¹⁶/bnl[+] is an enhancer of decreased occurrence of cell division | larval stage phenotype of trol^p4

(Park et al., 2003)

bnl⁰⁶⁹¹⁶/bnl[+] is an enhancer of decreased occurrence of cell division | larval stage phenotype of trol¹⁴

(Park et al., 2003)

Other

Statement

Reference

bnl⁰⁶⁹¹⁶/bnl[+], trol¹³ has decreased occurrence of cell division | larval stage phenotype

(Park et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

bnl⁰⁶⁹¹⁶/bnl[+] is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

bnl⁰⁶⁹¹⁶/bnl[+] is an enhancer of neuroblast | larval stage phenotype of trol^p4

(Park et al., 2003)

bnl⁰⁶⁹¹⁶/bnl[+] is an enhancer of neuroblast | larval stage phenotype of trol¹³

(Park et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

trol¹³/trol¹³; bnl⁰⁶⁹¹⁶/+ larvae have reduced numbers S phase neuroblasts per brain lobe compared to trol¹³ homozygotes. The reduction in S phase larval neuroblasts per brain lobe seen in trol^p4 homozygotes is enhanced by heterozygosity for bnl⁰⁶⁹¹⁶.

(Park et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

bnl^neo52

(BDGP Project Members, 1994-1999)

bnl⁰⁰⁸⁵⁷

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11704

ry⁵⁰⁶ P{PZ}bnl⁰⁶⁹¹⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: l(3)01344⁰¹³⁴⁴. Complements: l(3)05050⁰⁵⁰⁵⁰. Complements: Vha13⁰⁵¹¹³. Complements: Dl⁰⁵¹⁵¹. Complements: l(3)10585¹⁰⁵⁸⁵. Complements: l(3)neo53a¹.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

bnl⁰⁶⁹¹⁶

(Feuillette et al., 2020, Lindner et al., 2007)

bnl^P2

(Destalminil-Letourneau et al., 2021, Yan and Lin, 2007, Sutherland et al., 1996)

l(3)06916

(Spradling et al., 1999)

l(3)06916⁰⁶⁹¹⁶

l(3)6916

(Sutherland et al., 1996)

Name Synonyms

Secondary FlyBase IDs

FBal0057744

References (11)

Report Sections

Open Close