FlyBase Allele Report: Dmel\pan[13]

General Information

Symbol

Dmel\pan¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0011368

Feature type

allele

Associated gene

Dmel\pan

Associated Insertion(s)

Carried in Construct

Also Known As

l(4)13, 13

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Brunner et al., 1997)

Mutagen

X ray

(Hochman, 1976, Hochman, 1974, Hochman, 1971, Hochman et al., 1964)

Progenitor genotype

Cytology

Description

Insertion into the promoter region.

(van de Wetering et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Locke and Hanna, 1996, Hochman et al., 1964)

lethal - all die before end of larval stage | recessive

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

segment polarity phenotype

(Brunner et al., 1997)

some die during larval stage | recessive

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

Phenotype Manifest In

embryonic/larval cuticle

(Brunner et al., 1997)

embryonic/larval epidermis

(Brunner et al., 1997)

photoreceptor

(Boutros et al., 1998)

Detailed Description

Statement

Reference

Eyes of flies transheterozygous for pan¹³/pan^ER1 and raised at non-permissive temperature show normal polarity although some ommatidia contain extra photoreceptors.

(Boutros et al., 1998)

Homozygotes show a segment polarity phenotype in which the larval epidermis forms a lawn of ventral denticles and lacks naked cuticle between the segmental denticle belts. Individual denticles retain their correct polarity. The lawn of denticles phenotype is not suppressed when arm^{Δ.Scer\UAS.T:Ivir\HA1} is expressed using Scer\GAL4^hs.PB, indicating that pan acts downstream of arm.

(Brunner et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

pan¹³ is a suppressor of eye photoreceptor cell phenotype of Apc^Q8

(Ahmed et al., 1998)

NOT Suppressor of

Statement

Reference

pan¹³ is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Some photoreceptors are rescued from death in Apc^Q8 homozygotes carrying one copy of pan¹³.

(Ahmed et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

pan^ciD

(Brunner et al., 1997)

pan^ER1

(Brunner et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Second insertion of ci^D.

(van de Wetering et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

(Hochman, 1971, Hochman et al., 1964)

ci^102ABb-2

l(4)13

(Locke and Hanna, 1996, Tearle and Nusslein-Volhard, 1987, Hochman, 1976, Hochman, 1974)

pan¹³

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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