FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RpL36B46
Open Close
General Information
Symbol
Dmel\RpL36B46
Species
D. melanogaster
Name
FlyBase ID
FBal0011883
Feature type
allele
Associated gene
Dmel\RpL36
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Duffy et al., 1996)
Mutagen
ethyl nitrosourea
(Voelker et al., 1989, Eberl et al., 1988)
Progenitor genotype
Cytology
Description

Point mutant.

(Voelker et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows a dominant Minute phenotype: short fine bristles, delayed development and reduced viability. embryos have run-associated segmentation defects. This phenotype is suppressed by the maternal presence of P{1BD#1}. Reduced maternal RpL36 activity increases the penetrance and severity of the segmental defects observed in larvae heterozygous for Kr or kni mutations. Reduced maternal RpL36 activity has no effect on the larval or adult phenotypes of twi or Dl heterozygotes, or on the viability of Kr heterozygotes.

      (Duffy et al., 1996)

      Lethal phase is from early larval to the pupal stage.

      (Voelker et al., 1989)

      Recovered by Voelker in a screen for lethals in the vicinity of su(s). Lethality occurs between the first larval instar and pupation.

      (Eberl et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      RpL36B46 is an enhancer of phenotype of run3

      (Duffy et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 65% of run3 heterozygotes. When derived from RpL36B46/+ females, 57% of heterozygous run embryos have run-associated segmentation defects. Reduced maternal RpL36 activity increases the penetrance and severity of the segmental defects observed in larvae heterozygous for Kr or kni mutations. Reduced maternal RpL36 activity has no effect on the larval or adult phenotypes of twi or Dl heterozygotes, or on the viability of Kr heterozygotes.

      (Duffy et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      RpL36B46 is rescued by RpL36+t10

      (Duffy et al., 1996)

      RpL36B46 is rescued by RpL36+t10

      (Voelker et al., 1989)
      Comments

      Maternally supplied RpL36+t10 rescues the dominant Minute phenotype of RpL36B46 and its effects in heterozygous run mutant embryos.

      (Duffy et al., 1996)

      Lethality is rescued by RpL36+t10.

      (Voelker et al., 1989)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: Dp(1;3)E1.

      (Voelker et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      M(1)1BB46
      (Voelker et al., 1989)
      RpL36B46
      Name Synonyms
      Secondary FlyBase IDs
        References (4)