FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\RpL36
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General Information
Symbol
Dmel\RpL36
Species
D. melanogaster
Name
Ribosomal protein L36
Annotation Symbol
CG7622
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002579
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Component of the large ribosomal subunit. (UniProt, P49630)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

M(1)1B, M(1)Bld, EG:115C2.7 , l(1)G0471

Key Links
Genomic Location
Cytogenetic map
1B12-1B12
Sequence location
Recombination map
1-0
RefSeq locus
NC_004354 REGION:628338..629483
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables structural constituent of ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
inferred from direct assay
(Anger et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables structural constituent of ribosome
inferred from electronic annotation with InterPro:IPR000509
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000012121
(GO Reference Genome Project, 2011-)
traceable author statement
(Marygold et al., 2007)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cytoplasmic translation
inferred by curator from GO:0022626
(Anger et al., 2013, Alonso and Santaren, 2006)
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000012121
(GO Reference Genome Project, 2011-)
involved_in translation
inferred from electronic annotation with InterPro:IPR000509
(InterPro Project Members, 2004-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Rugjee et al., 2013)
located_in cytosolic ribosome
inferred from direct assay
(Anger et al., 2013)
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
colocalizes_with nuclear chromosome
inferred from direct assay
(Rugjee et al., 2013)
located_in nucleolus
inferred from direct assay
(Rugjee et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of cytosolic large ribosomal subunit
inferred from biological aspect of ancestor with PANTHER:PTN000012121
(GO Reference Genome Project, 2011-)
traceable author statement
(Marygold et al., 2007)
located_in ribosome
inferred from electronic annotation with InterPro:IPR000509
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eukaryotic ribosomal protein eL36 family. (P49630)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT -
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398.)
CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT -
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. Tissue expression data from modENCODE has been used to infer the composition of the cytosolic large ribosomal subunit testis-specific variant. (Adapted from FBrf0205398.)
Protein Function (UniProtKB)
Component of the large ribosomal subunit.
(UniProt, P49630)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
M(1)1B
Heterozygous deficiency for locus is extreme Minute of low viability. In Patterson's work, the nonappearance of Minutes led him to postulate a factor for viability (Vi). Eclosion delayed 76 hr (Ferrus, 1975, Genetics 79: 589-99). RK3A.
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\RpL36 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P49630)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RpL36-RA
FBtr0070155
NM_057281
568
115
RpL36-RB
FBtr0070156
NM_166853
555
115
RpL36-RC
FBtr0070158
NM_166854
592
115
RpL36-RD
FBtr0070157
NM_166855
535
115
RpL36-RE
FBtr0345321
NM_001297821
493
115
Additional Transcript Data and Comments
Reported size (kB)

3.5 (northern blot)

(Voelker et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
RpL36-PA
FBpp0070150
13.5
115
11.95
P49630
NP_476629
AAN09019
RpL36-PB
FBpp0070151
13.5
115
11.95
P49630
NP_726686
AAF45531
RpL36-PC
FBpp0070153
13.5
115
11.95
P49630
NP_726687
AAN09020
RpL36-PD
FBpp0070152
13.5
115
11.95
P49630
NP_726688
AAN09021
RpL36-PE
FBpp0311481
13.5
115
11.95
P49630
NP_001284750
AHN59221
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

115 aa isoforms: RpL36-PA, RpL36-PB, RpL36-PC, RpL36-PD, RpL36-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the large ribosomal subunit.

(UniProt, P49630)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL36 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.47

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Voelker et al., 1989)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Voelker et al., 1989)
Additional Descriptive Data

RpL36 transcripts are much more abundant in embryos than adults.

(Voelker et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Rugjee et al., 2013)
located_in cytosolic ribosome
inferred from direct assay
(Anger et al., 2013)
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
colocalizes_with nuclear chromosome
inferred from direct assay
(Rugjee et al., 2013)
located_in nucleolus
inferred from direct assay
(Rugjee et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpL36 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RpL36
Transgenic constructs containing regulatory region of RpL36
Aberrations (Deficiencies and Duplications) ( 94 )
Inferred from experimentation ( 94 )
Gene disrupted in
Df(1)BA1
(Marygold et al., 2007)
Df(1)su(s)2
(Voelker et al., 1989)
Df(1)su(s)3
(Voelker et al., 1989)
Df(1)su(s)83
(Marygold et al., 2007, Duffy et al., 1996, Voelker et al., 1989)
Df(1)su(s)R194
(Marygold et al., 2007, Duffy et al., 1996)
Df(1)svr
(Duffy et al., 1996)
Df(1)y74k24.1
(Duffy et al., 1996)
Df(1)yT8-206
(Voelker et al., 1989)
Df(1)yT12-173
(Voelker et al., 1989)
Df(1)yT12-187
(Voelker et al., 1989)
Df(1)yT12-200
(Voelker et al., 1989)
Df(1)yT12-246
(Voelker et al., 1989)
Df(1)yT12-667
(Voelker et al., 1989)
Df(1)yT13-423
(Voelker et al., 1989)
Df(1)yT13-464
(Voelker et al., 1989)
Df(1)yT14-546
(Voelker et al., 1989)
Df(1)yT14-576
(Voelker et al., 1989)
Df(1)yT15-5
(Voelker et al., 1989)
Df(1)yT15-6
(Voelker et al., 1989)
Df(1)yT15-28
(Voelker et al., 1989)
Df(1)yT15-56
(Voelker et al., 1989)
Df(1)yT15-105
(Voelker et al., 1989)
Df(1)yT15-158b
(Voelker et al., 1989)
Df(1)yT15-161
(Voelker et al., 1989)
Df(1)yT15-171
(Voelker et al., 1989)
Df(1)yT15-177
(Voelker et al., 1989)
Df(1)yT15-183
(Voelker et al., 1989)
Df(1)yT15-189
(Voelker et al., 1989)
Df(1)yT15-219
(Voelker et al., 1989)
Df(1)yT15-222
(Voelker et al., 1989)
Df(1)yT15-270
(Voelker et al., 1989)
Df(1)yT15-274
(Voelker et al., 1989)
Df(1)yT15-286
(Voelker et al., 1989)
Df(1)yT15-300
(Voelker et al., 1989)
Df(1)yT15-318
(Voelker et al., 1989)
Df(1)yT15-325
(Voelker et al., 1989)
Df(1)yT15-327
(Voelker et al., 1989)
Df(1)yT15-334
(Voelker et al., 1989)
Df(1)yT15-364
(Voelker et al., 1989)
Df(1)yT15-365
(Voelker et al., 1989)
Df(1)yT15-383
(Voelker et al., 1989)
Df(1)yT15-390
(Voelker et al., 1989)
Df(1)yT15-392
(Voelker et al., 1989)
Df(1)yT15-405
(Voelker et al., 1989)
Df(1)yT15-408
(Voelker et al., 1989)
Df(1)yT15-410
(Voelker et al., 1989)
Df(1)yT15-412
(Voelker et al., 1989)
Df(1)yT15-433
(Voelker et al., 1989)
Df(1)yT15-449
(Voelker et al., 1989)
Df(1)yT15-460
(Voelker et al., 1989)
Df(1)yT15-468
(Voelker et al., 1989)
Df(1)yT15-502
(Voelker et al., 1989)
Df(1)yT15-509
(Voelker et al., 1989)
Df(1)yT15-511
(Voelker et al., 1989)
Df(1)yT15-517
(Voelker et al., 1989)
Df(1)yT15-533
(Voelker et al., 1989)
Df(1)yT15-543
(Voelker et al., 1989)
Df(1)yT15-548
(Voelker et al., 1989)
Df(1)yT15-552
(Voelker et al., 1989)
Df(1)yT15-564
(Voelker et al., 1989)
Df(1)yT15-568
(Voelker et al., 1989)
Df(1)yT15-575
(Voelker et al., 1989)
Df(1)yT15-586
(Voelker et al., 1989)
Df(1)yT15-597
(Voelker et al., 1989)
Df(1)yT15-599
(Voelker et al., 1989)
Df(1)yT16-14
(Voelker et al., 1989)
Df(1)yT16-411
(Voelker et al., 1989)
Df(1)yT16-499
(Voelker et al., 1989)
Df(1)yT16-534
(Voelker et al., 1989)
Df(1)yT16-554
(Voelker et al., 1989)
Df(1)yT17-570
(Voelker et al., 1989)
Df(1)yT17-600
(Voelker et al., 1989)
Df(1)yT18-319
(Voelker et al., 1989)
Df(1)yT19-16
(Voelker et al., 1989)
Df(1)yT19-253
(Voelker et al., 1989)
Dp(1;3)su(s)E2
(Voelker et al., 1989)
T(1;3)scJ4
(Marygold et al., 2007)
Ts(1Rt;2Rt)Bld
(Ferrus, 1975)
Gene duplicated in
Dp(1;3)DC009
(Popodi et al., 2010-, Venken et al., 2010)
Dp(1;3)DC010
(Popodi et al., 2010-, Venken et al., 2010)
Dp(1;3)DC011
(Popodi et al., 2010-, Venken et al., 2010)
Ts(1Lt;2Lt)Bld
Gene not disrupted in
Df(1)scV1
Df(1)y74k10.1
(Voelker et al., 1989)
Df(1)y74k24.1
(Voelker et al., 1989)
Df(1)yT9-7
(Voelker et al., 1989)
Df(1)yT9-21
(Voelker et al., 1989)
Df(1)yT9-220
(Voelker et al., 1989)
Df(1)yT9-275
(Voelker et al., 1989)
Df(1)yT10-102
(Voelker et al., 1989)
Df(1)yT10-106
(Voelker et al., 1989)
Df(1)yT10-581
(Voelker et al., 1989)
Df(1)yT10-665
(Voelker et al., 1989)
Df(1)yT10-673
(Voelker et al., 1989)
Df(1)yT10-677
(Voelker et al., 1989)
Inferred from location ( 13 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\RPL36
11 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\LOC100361079
12 of 14
Yes
Yes
Rnor\Rpl36
12 of 14
Yes
Yes
Rnor\LOC100360439
11 of 14
No
Yes
Rnor\LOC100359616
10 of 14
No
Yes
Rnor\LOC100361060
10 of 14
No
Yes
Rnor\LOC103691423
10 of 14
No
Yes
Rnor\LOC120096659
10 of 14
No
Yes
Rnor\RGD1564268
8 of 14
No
Yes
Rnor\RGD1564730
6 of 14
No
Yes
Rnor\LOC120097397
4 of 14
No
Yes
Rnor\RGD1563135
1 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Rpl36
12 of 14
Yes
Yes
Mmus\Rpl36-ps4
5 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\rpl36
11 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\rpl36
12 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\rpl-36
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP002921
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\AT2G37600
13 of 13
Yes
Yes
Atha\AT3G53740
13 of 13
Yes
Yes
Atha\AT5G02450
13 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\RPL36A
12 of 13
Yes
Yes
Scer\RPL36B
12 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\rpl3601
11 of 12
Yes
Yes
Spom\rpl3602
11 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:RpL36. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RPL36; ribosomal protein L36
11 of 14
617893
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      RpL36 - InR
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      RpL36 - Rack1
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - Rheb
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      RpL36 - RpL10
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL10Ab
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL11
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL12
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL13
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL13A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL14
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL15
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL17
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL18
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL18A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL19
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL21
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL22
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL23
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL23A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL24
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL26
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL27
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL27A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL28
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL29
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL3
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL30
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL31
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL32
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL34a
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL35
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL35A
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL36A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL37-1
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL37A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL38
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL39
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL4
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL40
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL41
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL5
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL6
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL7
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL7A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL8
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpL9
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpLP0
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpLP1
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpLP2
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS10a
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS11
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS12
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS13
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS14a
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS14b
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS15
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS15Aa
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS16
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS17
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS18
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS19a
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS2
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS20
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS21
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS23
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS24
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS25
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS26
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS27
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS27A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS28b
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS29
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS3
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS30
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS3A
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS4
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS5a
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS6
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS7
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS8
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - RpS9
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - S6kII
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      RpL36 - Thor
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      RpL36 - eEF2
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - gig
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      RpL36 - rictor
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      RpL36 - sta
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RpL36 - vig2
      cosedimentation, Identification by mass spectrometry, electron microscopy
      (Anger et al., 2013)
      RNA-protein
      Physical Interaction
      Assay
      References
      RpL36 - 18SrRNA
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - 28SrRNA
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - 2SrRNA
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - 5.8SrRNA
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      RpL36 - 5SrRNA
      cosedimentation, electron microscopy
      (Anger et al., 2013)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      run
      enhanceable
      RpL36
      (Duffy et al., 1996)
      External Data
      Subunit Structure (UniProtKB)
      Component of the large ribosomal subunit.
      (UniProt, P49630 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-0
      Cytogenetic map
      1B12-1B12
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      1B12-1B12
      Limits computationally determined from genome sequence between P{EP}svrEP356&P{EP}argEP452 and P{EP}DreddEP1412&P{EP}Suv4-20EP1216a
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      1B11-1B14
      (determined by in situ hybridisation)
      (Peter et al., 2002, Schäfer et al., 1999.12.2)
      1B13-1C1
      (Voelker et al., 1989)
      Experimentally Determined Recombination Data
      Location

      1-0

      (FlyBase, 2016)

      1-0.0

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      (Garcia-Bellido, 1979)
      Notes
      Stocks and Reagents
      Stocks (9)
      Genomic Clones (15)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (535)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Haploinsufficient locus.

            (Cook et al., 2012)

            Minute gene.

            (Marygold et al., 2007)

            Deletions removing RpL36 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes.

            (Marygold et al., 2007)

            RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

            (Boutros et al., 2004)

            "Gene order: In direction of increasing cytology: RpL36+ l(1)1Bi+ Dredd- su(s)+" was stated as revision.

            (Chen et al., 1998)

            "Gene order: In direction of increasing cytology: RpL36? l(1)1Bi+ Dredd- su(s)+ CG13367? l(1)1Bk?" was stated as revision.

            (Rodriguez, 1997.9.8)

            RpL36 affects posterior pattern formation and acts, perhaps indirectly, as a dosage sensitive maternal modifier of run.

            (Duffy et al., 1996)

            FlyBase curator comment: Gene order described in this paper is "l(1)1Bi? RpL36+ Dredd- su(s)+ CG13367? l(1)1Bk?". FBrf0098592 subsequently reversed the order of l(1)1Bi and RpL36.

            (Voelker et al., 1989)

            Mutant alleles have the developmental delay and bristle phenotype that makes them useful as markers in clonal analysis.

            (Lawrence et al., 1986)

            One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development. Heterozygous deficiency for locus is extreme Minute of low viability. In Patterson's work, the nonappearance of Minutes led him to postulate a factor for viability (Vi). Eclosion delayed 76 hr (Ferrus, 1975).

            Relationship to Other Genes
            Source for database merge of

            Source for merge of: RpL36 l(1)G0471

            (Peter et al., 2002)

            Source for merge of: RpL36 BcDNA:AT29875

            (FlyBase, 1996-)
            Additional comments

            Source for merge of RpL36 BcDNA:AT29875 was a shared cDNA ( date:030728 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: RpL36 CG7622

            (Nusskern, 1999.11)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (19)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 61 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            PDB - An information portal to biological macromolecular structures
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (96)