FlyBase Allele Report: Dmel\Sams[1]

General Information

Symbol

Dmel\Sams¹

Species

D. melanogaster

Name

FlyBase ID

FBal0011886

Feature type

allele

Associated gene

Dmel\Sams

Associated Insertion(s)

Carried in Construct

Also Known As

Su(z)5¹, Su(z)5, Sam-S¹

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kalisch and Rasmuson, 1974)

Progenitor genotype

Cytology

Polytene chromosomes apparently normal.

Description

2.9kb insertion.

(Larsson et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2L)ED5878)

(Miller et al., 2020, Kahsai and Cook, 2018)

lethal (with Df(2L)Exel6001)

(Miller et al., 2020)

lethal (with Df(2L)net18)

(Miller et al., 2020)

lethal (with Df(2L)PM44)

(Miller et al., 2020)

lethal (with Df(2L)PMG)

(Kahsai and Cook, 2018)

lethal (with Sams^R23)

(Miller et al., 2020, Kahsai and Cook, 2018)

lethal | recessive

(Larsson and Rasmuson-Lestander, 1998, Kalisch and Rasmuson, 1974)

lethal - all die during embryonic stage | recessive

(Larsson et al., 1996, Larsson et al., 1995)

some die during embryonic stage | recessive

(Larsson et al., 1996, Larsson et al., 1995)

suppressor of variegation | dominant, with In(1)w^m4, w^sp1

(Larsson et al., 1996)

Phenotype Manifest In

eye

(Kalisch and Rasmuson, 1974)

Detailed Description

Statement

Reference

Homozygotes die during the late embryonic and first larval instar stages.

(Larsson and Rasmuson-Lestander, 1998)

Dominant suppressor of z¹ w^is mutant phenotype. Fails to suppress the mutant phenotype of z¹ w^+UZ, z¹ Dp(1;1)w⁺61e19, z¹ w^sp2, z¹ w^sp55, z¹ w^negro, z¹ w^zm, z¹ w^ch and z¹ w^a, w^a, w^a2, w^bf2, w^bfR61d5, w^bf, w^h and w^co individuals.

(Larsson et al., 1996)

Heterozygotes have reduced viability. Females fertile at 16^oC but sterile at 25^oC.

(Kalisch and Rasmuson, 1974)

Body size and bristles reduced in heterozygotes; irregular facets in upper half of eye. Heterozygous females virtually sterile at temperatures above 18^oC; surviving offspring frequently have missing legs or halteres, somewhat narrowed wings, and reduced bristles. Homozygotes lethal. Selected on the basis of a dominant suppressor of zeste phenotype. Characterized by relatively frequent reversions of all features of the phenotype save homozygous lethality. One such revertant found to be deficient for the tip of 2L, suggesting a gain of function rather than haplo insufficiency as the nature of the mutation (Kennison).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

M(2)21AB[+]/Sams¹ is a suppressor of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sams¹ is an enhancer of phenotype of Pc¹¹

(Larsson et al., 1996)

Suppressor of

Statement

Reference

M(2)21AB[+]/Sams¹ is a suppressor of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Sams¹ is a suppressor of phenotype of z¹

(Larsson et al., 1995, Kalisch and Rasmuson, 1974)

Additional Comments

Genetic Interactions

Statement

Reference

Suppresses the z¹-mediated repression of w. Heterozygotes that are also z^- show extreme reduction in viability, small bristles and deformed wings. Suppresses In(1)w^m4 and in combination with Pc enhances the number of sex combs on the midleg and the number of teeth per sex comb.

(Larsson et al., 1995)

Very strong suppression of the z/w interaction causing darkening of the eye pigmentation. In combination of z and w^is with M(2)21AB¹ gives a specific eye phenotype in females, the front half of the eye is darker than the hind.

(Kalisch and Rasmuson, 1974)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

complements l(2)gl.

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

6305

Sams¹/CyO, P{ftz-lacC}USC1

Kyoto

108972

Sams¹/CyO, P{ftz-lacC}USC1

101532

Sams¹/CyO, P{ftz-lacC}USC1, Duox^Cy dpy^lv1 pr¹ cn²

Notes on Origin

Discoverer

Comments

Somatic clonal analysis indicates that M(2)21AB is required for cell proliferation or growth during development of the eye imaginal disc.

(Larsson and Rasmuson-Lestander, 1998)

Mutant has lost the developmental delay, the Minute characteristics and the female temperature sensitive sterility previously described in FBrf0028903.

(Larsson et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

M(2)21AB¹

Sam-S¹

(Miller et al., 2020, Kahsai and Cook, 2018)

Sams¹

Su(z)5

(Larsson and Rasmuson-Lestander, 1998, Larsson et al., 1996, Larssen et al., 1994)

Su(z)5¹

(Gildea et al., 2000, Larsson et al., 1995, Kalisch and Rasmuson, 1974)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close