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General Information
Symbol
Dmel\Sam-S1
Species
D. melanogaster
Name
FlyBase ID
FBal0011886
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(z)51, Su(z)5
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes apparently normal.

Nature of the lesion
Statement
Reference

2.9kb insertion.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes die during the late embryonic and first larval instar stages.

Dominant suppressor of z1 wis mutant phenotype. Fails to suppress the mutant phenotype of z1 w+UZ, z1 Dp(1;1)w+61e19, z1 wsp2, z1 wsp55, z1 wnegro, z1 wzm, z1 wch and z1 wa, wa, wa2, wbf2, wbfR61d5, wbf, wh and wco individuals.

Heterozygotes have reduced viability. Females fertile at 16oC but sterile at 25oC.

Body size and bristles reduced in heterozygotes; irregular facets in upper half of eye. Heterozygous females virtually sterile at temperatures above 18oC; surviving offspring frequently have missing legs or halteres, somewhat narrowed wings, and reduced bristles. Homozygotes lethal. Selected on the basis of a dominant suppressor of zeste phenotype. Characterized by relatively frequent reversions of all features of the phenotype save homozygous lethality. One such revertant found to be deficient for the tip of 2L, suggesting a gain of function rather than haplo insufficiency as the nature of the mutation (Kennison).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

M(2)21AB[+]/Sam-S1 is a suppressor of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

Phenotype Manifest In
Enhancer of
Statement
Reference

Sam-S1 is an enhancer of phenotype of Pc11

Suppressor of
Statement
Reference

M(2)21AB[+]/Sam-S1 is a suppressor of adult metathoracic segment phenotype of brm[+]/brm2, trxE2

Sam-S1 is a suppressor of phenotype of z1

Additional Comments
Genetic Interactions
Statement
Reference

Suppresses the z1-mediated repression of w. Heterozygotes that are also z- show extreme reduction in viability, small bristles and deformed wings. Suppresses In(1)wm4 and in combination with Pc enhances the number of sex combs on the midleg and the number of teeth per sex comb.

Very strong suppression of the z/w interaction causing darkening of the eye pigmentation. In combination of z and wis with M(2)21AB1 gives a specific eye phenotype in females, the front half of the eye is darker than the hind.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

complements l(2)gl.

Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer
Comments
Comments

Somatic clonal analysis indicates that M(2)21AB is required for cell proliferation or growth during development of the eye imaginal disc.

Mutant has lost the developmental delay, the Minute characteristics and the female temperature sensitive sterility previously described in FBrf0028903.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (8)