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General Information
Symbol
Dmel\mam8
Species
D. melanogaster
Name
FlyBase ID
FBal0012016
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
mamIJ113
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Midline glia are present in mam8 mutant stage 16 embryos but appear disorganised compared to wild type.

Midline glia are present in mam8/mamΔC mutant stage 16 embryos but appear disorganised in comparison with wild type.

Homozygous mutant follicle stem cell clones are present at a much lower frequency than control clones at 7 days (30% vs 73%) and 14 days (8% vs 57%) after clone induction.

Ovarioles that include mutant follicle cells show frequent egg chamber fusions.

Homozygous clones in the developing eye have no effect on eye development.

Embryonic CNS exhibits severe disturbances and larval exhibit severe cuticle loss.

Embryos exhibit fused muscles in patterned arrangements, particularly in the more dorsal regions of the embryo. The birefringent is clearly correlated with the expansion of the CNS and PNS, and the loss of epidermis and the degree to which myoblast fusion occurs. Where myoblast fusion fails conspicuous clusters of mesodermal cells are formed and if epidermal territories are expanded cells in these clusters may be recruited to fusion.

Intermediate neurogenic phenotype.

Homozygous embryos have a greatly enlarged ventral nerve cord.

mam8 shows weak neural hypertrophy, a 2-5 fold increase in nau expressing cells per cluster relative to wild type.

The anterior end of the embryo is filled with neural cells and the ventral nerve cord is expanded.

Intermediate embryonic neurogenic phenotype.

stronger allele

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Suppressor of
Statement
Reference

mam8/mam[+] is a suppressor of phenotype of hhhs.PI

Additional Comments
Genetic Interactions
Statement
Reference

The phenotype of excess follicle stem cell progeny in between egg chambers that is caused by expression of hhhs.PI using heat shock twice daily for 3 days followed by a 3 day "chase" is dominantly suppressed by mam8, such that the number of inappropriate cells between egg chambers is strongly reduced.

mam8 prevents the duplication of follicle stem cells that is normally seen in ptcS2 follicle stem cell clones.

Expression of Nintra.GS.Scer\UAS under the control of Scer\GAL4tub has no effect on the maintenance of mam8 follicle stem cell clones.

Expression of Su(H)Scer\UAS.cSa.T:Hsim\VP16 under the control of Scer\GAL4tub has no effect on the maintenance of mam8 follicle stem cell clones.

No significant effect on the scaMSKF mutant phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (24)