Midline glia are present in mam8 mutant stage 16 embryos but appear disorganised compared to wild type.
Midline glia are present in mam8/mamΔC mutant stage 16 embryos but appear disorganised in comparison with wild type.
Homozygous mutant follicle stem cell clones are present at a much lower frequency than control clones at 7 days (30% vs 73%) and 14 days (8% vs 57%) after clone induction.
Ovarioles that include mutant follicle cells show frequent egg chamber fusions.
Homozygous clones in the developing eye have no effect on eye development.
Embryonic CNS exhibits severe disturbances and larval exhibit severe cuticle loss.
Embryos exhibit fused muscles in patterned arrangements, particularly in the more dorsal regions of the embryo. The birefringent is clearly correlated with the expansion of the CNS and PNS, and the loss of epidermis and the degree to which myoblast fusion occurs. Where myoblast fusion fails conspicuous clusters of mesodermal cells are formed and if epidermal territories are expanded cells in these clusters may be recruited to fusion.
Intermediate neurogenic phenotype.
Homozygous embryos have a greatly enlarged ventral nerve cord.
mam8 shows weak neural hypertrophy, a 2-5 fold increase in nau expressing cells per cluster relative to wild type.
The anterior end of the embryo is filled with neural cells and the ventral nerve cord is expanded.
Intermediate embryonic neurogenic phenotype.