FlyBase Allele Report: Dmel\nod[3]

General Information

Symbol

Dmel\nod³

Species

D. melanogaster

Name

FlyBase ID

FBal0013067

Feature type

allele

Associated gene

Dmel\nod

Associated Insertion(s)

Carried in Construct

Also Known As

nod^b17

Key Links

Allele class

loss of function allele

Mutagen

gamma ray

Nature of the Allele

Allele class

loss of function allele

(Zhang and Hawley, 1990)

Mutagen

gamma ray

(Rasooly et al., 1994)

Progenitor genotype

Cytology

Description

Deletion of 0.5kb, from bases 3581 to 4317, and an insertion of 82bp from the unique region 5' of the third repeat. Resulting protein is 34 residues shorter than wild type and 13 amino acids are completely novel.

(Rasooly et al., 1994)

0.5kb deletion, removing the 3' end of the coding region.

(Knowles and Hawley, 1991)

0.5 kb deletion at position +4.2.

(Zhang et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | recessive

(Zhang and Hawley, 1990)

Phenotype Manifest In

Detailed Description

Statement

Reference

Transmission rate of Dp(1;f)J21A through females to progeny is 28%, the nod mutation strongly decreases transmission. Mutation also decreases transmission of Dp(1;f)1B, Dp(1;f)25A and Dp(1;f)10B.

(Cook et al., 1997)

Transmission of Dp(1;f)1187 is reduced from 52% to 3% in homozygous nod³ females and to 47% in nod³/+ females. Severe alleles of nod reduce the transmission of the Dp(1;f)1187 derivative P{PZ}8-23 more than weaker alleles (nod^DTW > nod^DR3 >= nod³). nod³ increases nondisjunction of Dp(1;f)1187 derivatives Dp(1;f)γ1230 and Dp(1;f)γ878.

(Murphy and Karpen, 1995)

High levels of X and fourth chromosome nondisjunction. Hemizygotes exhibit a strong nod phenotype.

(Zhang and Hawley, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

nod³ has abnormal meiotic cell cycle phenotype, enhanceable by neb[+]/neb^TE8

(Ruden et al., 1997)

nod³ has abnormal meiotic cell cycle phenotype, enhanceable by neb[+]/neb^TE12

(Ruden et al., 1997)

nod³ has abnormal meiotic cell cycle phenotype, enhanceable by neb[+]/neb^TE20

(Ruden et al., 1997)

Enhancer of

Statement

Reference

nod[+]/nod³ is an enhancer of abnormal meiotic cell cycle phenotype of neb^TE12

(Ruden et al., 1997)

nod[+]/nod³ is an enhancer of abnormal meiotic cell cycle phenotype of neb^TE8

(Ruden et al., 1997)

nod[+]/nod³ is an enhancer of abnormal meiotic cell cycle phenotype of neb^TE20

(Ruden et al., 1997)

Suppressor of

Statement

Reference

nod³ is a suppressor of abnormal meiotic cell cycle | dominant phenotype of αTub67C^P40Δ

(Matthies et al., 1999)

nod³ is a suppressor of abnormal meiotic cell cycle | dominant phenotype of αTub67C^P40

(Matthies et al., 1999)

Other

Statement

Reference

neb^TE2, nod³ has female sterile | dominant phenotype

(Ruden et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

nod³ has phenotype, enhanceable by ncd¹

(Knowles and Hawley, 1991)

Suppressor of

Statement

Reference

nod³ is a suppressor of oocyte & chromatin phenotype of αTub67C^P40

(Matthies et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Ova from neb^TE8/+ (or neb^TE12/+ or neb^TE20/+) nod²/+ (or nod³/+ or nod⁴/+) transheterozygous females show a higher rate of 4th chromosome nondisjunction (up to 21%) than females heterozygous for either mutation alone. Transheterozygotes with neb^TE2 are sterile.

(Ruden et al., 1997)

ncd¹ nod³ heterozygous females show an increased level of X and fourth chromosome nondisjunction.

(Knowles and Hawley, 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

nod³ is partially rescued by nod^hs.Tag:FLAG

(Cook et al., 1997)

Comments

One or two extra copies of nod provided by nod^{hs.T:Zzzz\FLAG} partially rescues transmission of Dp(1;f)J21A and Dp(1;f)10B.

(Cook et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

3426

FM7a, nod³/Dp(1;Y)y⁺/C(1)DX, y¹ f¹; sv^spa-pol

Notes on Origin

Discoverer

Induced on: In(1)FM7, y^31d sc⁸ w^a B v^Of.

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

M94188

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

nod³

nod^b17

(Matthies et al., 1999, Cook et al., 1997, Murphy and Karpen, 1995, Rasooly et al., 1994, Knowles and Hawley, 1991, Zhang and Hawley, 1990, Zhang et al., 1990)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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