FlyBase Allele Report: Dmel\neb[TE2]

General Information

Symbol

Dmel\neb^TE2

Species

D. melanogaster

Name

FlyBase ID

FBal0082409

Feature type

allele

Associated gene

Dmel\neb

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Ruden et al., 1997)

Mutagen

ethyl methanesulfonate

(Ruden et al., 1997)

Progenitor genotype

Cytology

Description

Mutation resulting in a stop codon after the DNA binding and motor domain.

(Ruden et al., 1997)

Amino acid replacement: Q1014term.

(Ruden et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:20,089,246..20,089,246 [+]

Nucleotide change:

C20089246T

Amino acid change:

Q1014term | neb-PA

Reported amino acid change:

Q1014term

(Ruden et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Ruden et al., 1997)

partially lethal - majority die | recessive

(Ruden et al., 1997)

some die during larval stage | recessive

(Ruden et al., 1997)

Phenotype Manifest In

embryonic/first instar larval cuticle | germline clone

(Ruden et al., 1997)

embryonic abdominal segment | germline clone

(Ruden et al., 1997)

embryonic epidermis | germline clone

(Ruden et al., 1997)

embryonic head | germline clone

(Ruden et al., 1997)

interommatidial bristle

(Ruden et al., 1997)

macrochaeta

(Ruden et al., 1997)

wing

(Ruden et al., 1997)

Detailed Description

Statement

Reference

Mutant embryos derived from germline clones have holes in cuticle, are missing abdominal segments and have head involution defects. Escapers have many missing bristles, behavioural defects and wings held out perpendicular to the body.

(Ruden et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

neb^TE2, nod² has female sterile | dominant phenotype

(Ruden et al., 1997)

neb^TE2, nod³ has female sterile | dominant phenotype

(Ruden et al., 1997)

neb^TE2, nod⁴ has female sterile | dominant phenotype

(Ruden et al., 1997)

Phenotype Manifest In

Suppressor of

Statement

Reference

neb^TE2 is a suppressor of phenotype of kni^unspecified

(Ruden et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous females transheterozygous with nod², nod³ or nod⁴ are sterile.

(Ruden et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong allele.

(Ruden et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

neb^TE2

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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