FlyBase Allele Report: Dmel\mys[olfC-x3]

General Information

Symbol

Dmel\mys^olfC-x3

Species

D. melanogaster

Name

FlyBase ID

FBal0013246

Feature type

allele

Associated gene

Dmel\mys

Associated Insertion(s)

Carried in Construct

Also Known As

olfC^X3

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal smell perception

(Ayyub and Paranjape, 2002)

abnormal smell perception (with mys^olfC-x5)

(Ayyub et al., 2000)

abnormal smell perception (with mys^olfC-x10)

(Ayyub et al., 2000)

abnormal smell perception (with mys^olfC-x17)

(Ayyub et al., 2000)

abnormal smell perception | recessive

(Ayyub et al., 2000, Ayyub et al., 1990)

Phenotype Manifest In

Detailed Description

Statement

Reference

In the odour-induced jump test, homozygous mutants of mys^olfC-x3 are defective in response to ethyl acetate and iso-amyl acetate but not benzaldehyde, when compared to controls.

(Ayyub and Paranjape, 2002)

Mutants exhibit reduced olfactory responses to isoamyl acetate and ethyl acetate, whether homozygous or in combination with mys^olfC-x5, mys^olfC-x10 or mys^olfC-x17.

(Ayyub et al., 2000)

Homozygous adults show a reduced attraction to both ethyl acetate and iso-amyl acetate compared to wild-type in a slow chemotaxis assay and an odor-induced jump assay. Homozygous larvae also show a reduced attraction to both ethyl acetate and iso-amyl acetate. Responses of larvae and adults to benzaldehyde, propionic acid and butanol are normal. mys^olfC-x3/mys^olfC-x5 flies are defective in their responses to both ethyl acetate and iso-amyl acetate.

(Ayyub et al., 1990)

reduced attraction to both ethyl and iso-amyl acetate mys^olfC-x3 over olfC deletion behaves with same poor responses to acetates as does homozygous mutant

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

mew^M6, mys^olfC-x3/mys[+] has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

Df(1)C128, mys^olfC-x3 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

mew^M6, mys^olfC-x3 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

if^B2, mys^olfC-x3 has abnormal smell perception phenotype

(Ayyub et al., 2000)

if^k27e, mys^olfC-x3 has abnormal smell perception phenotype

(Ayyub et al., 2000)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

In the odour-induced jump test, mutants with the transheterozygous combination of mys^olfC-x3 with sws^olfE-x26 show normal response to iso-amyl acetate, ethyl acetate and benzaldehyde, compared to controls.

When tested in the odour-induced jump-test, double heterozygotes of mew^M6 and mys^olfC-x3 show reduced responses to both ethyl acetate and iso-amyl acetate.

Mutants with mys^olfC-x3 in transheterozygosity to Df(1)C128 (which removes both sws and mys) show defects in response to iso-amyl acetate but not benzaldehyde compared to controls, when tested in the odour-induced jump test.

(Ayyub and Paranjape, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mys^{olfC-A459.1F1}

(Ayyub et al., 2000)

mys¹⁰

(Ayyub et al., 2000)

mys⁸

(Ayyub et al., 2000)