FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Scm5
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General Information
Symbol
Dmel\Scm5
Species
D. melanogaster
Name
FlyBase ID
FBal0015269
Feature type
allele
Associated gene
Dmel\Scm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Bornemann et al., 1998)
Mutagen
ethyl methanesulfonate
(Bornemann et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: V227E.

(Bornemann et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,636,418..9,636,418 [-]
Nucleotide change:

T9636418A

Amino acid change:

V227E | Scm-PA; V227E | Scm-PB

Reported amino acid change:

V227E|FBrf0104734

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bornemann et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygotes die during the second larval instar stage.

      (Bornemann et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Scm5 is an enhancer of visible | dominant | homeotic phenotype of Pc3

      (Bornemann et al., 1998)
      Other
      Statement
      Reference

      Scm5, ph-p409 has partially lethal phenotype

      (Bornemann et al., 1998)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scm5 is a suppressor of phenotype of z1

      (Bornemann et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the homeotic phenotypes of Pc3/+ adults. ph-p409 males that are also heterozygous for Scm5 show partial lethality.

      (Bornemann et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Scm4

      (Bornemann et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      K. Matthews.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scm5
      ScmKM23
      (Bornemann et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)