FlyBase Allele Report: Dmel\Tl[rv19]

General Information

Symbol

Dmel\Tl^rv19

Species

D. melanogaster

Name

FlyBase ID

FBal0016861

Feature type

allele

Associated gene

Dmel\Tl

Associated Insertion(s)

Carried in Construct

Also Known As

Tl^9QRE, Toll^9QRE

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Belvin et al., 1995, Gerttula et al., 1988, Tearle and Nusslein-Volhard, 1987)

loss of function allele

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

Progenitor genotype

Tl³

(Anderson et al., 1985)

Caused by aberration

In(3R)Tl^rv19

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

amnioserosa (with Tl^r2)

(Stronach and Perrimon, 2001)

dorsal ectoderm (with Tl^r2)

(Stronach and Perrimon, 2001)

embryonic leading edge cell (with Tl^r2)

(Stronach and Perrimon, 2001)

Detailed Description

Statement

Reference

embryos laid by Tl^r2/Tl^rv19 mothers are dorsalised. They display differentiating amnioserosa tissue around the entire central region of the embryo. Leading edge (LE) and dorsal ectoderm are also formed in these embryos but their axial arrangement is reoriented nearly 90^o. Consequently LE cells are arrayed around the dorsal ventral circumference of the embryos, rather than in an anterior to posterior orientation. However, they remain in a single row configuration between amnioserosa and dorsal ectoderm cells. many embryos display a non-uniform distribution of amnioserosa and dorsal ectoderm.

(Stronach and Perrimon, 2001)

Mutant embryos do not respond to injected purified polarizing activity (spz).

(Schneider et al., 1994)

Incompletely penetrant dominant dorsalization.

(Chasan et al., 1992)

Dorsalized phenotype facilitates removal of perivitelline fluid.

(Stein and Nusslein-Volhard, 1992)

Does not interact with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Tl^rv19 is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

Tl^rv19 is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Tl^rv19 is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

Tl^rv19 is a suppressor of phenotype of ea^D1

(Chasan et al., 1992)

Tl^rv19 is a suppressor of phenotype of ea^D3

(Chasan et al., 1992)

NOT Suppressor of

Statement

Reference

Tl^rv19 is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Perivitelline fluid from embryos laid by Tl^rv13/Tl^rv19 females shows polarising activity when injected into the perivitelline space of embryos derived from pip¹/pip² females.

(Chang and Morisato, 2002)

The addition of Tl^rv19/+ or baz^692-44/+ has no effect on Df(2R)a^EX1/+ flies.

(Liu and Lengyel, 2000)

Dominant suppressor of dominant ea ventralizing mutants. Double mutant combinations with ea^D1 are strongly dorsalizing.

(Chasan et al., 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant.

(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

Comments

Injection of spz into Tl^- embryos does not cause rapid degradation of cact.

(Belvin et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

9QRE

(Riede, 2001)

Df(3R)Tl^9QRE

(Morisato, 2001)

Tl^9Q-RE

(Tearle and Nusslein-Volhard, 1987)

Tl^9QRE

(Bach et al., 2003, Chang and Morisato, 2002, Stronach and Perrimon, 2001, Liu and Lengyel, 2000, Levashina et al., 1999, Manfruelli et al., 1999, Ferrandon et al., 1998, Levashina et al., 1998, Misra et al., 1998, Casal and Leptin, 1996, Belvin et al., 1995, Morisato and Anderson, 1994, Schneider et al., 1994, Chasan et al., 1992, Stein and Nusslein-Volhard, 1992, Parkhurst and Ish-Horowicz, 1991, Roth et al., 1991, Gerttula et al., 1988, Anderson et al., 1985)

Tl^rv19

Tl^ts

(Stronach and Perrimon, 2001)

Toll^9QRE

(Lagueux et al., 2000, Leptin et al., 1992)

Name Synonyms

Tollrv19

(Stein et al., 2010)

Secondary FlyBase IDs

References (26)

Report Sections

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