FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rho5
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General Information
Symbol
Dmel\rho5
Species
D. melanogaster
Name
FlyBase ID
FBal0017859
Feature type
allele
Associated gene
Dmel\rho
Associated Insertion(s)
P{lacW}rho5
Carried in Construct
Also Known As
rholac1
Key Links
Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Bier et al., 1990)

loss of function allele

(zur Lage et al., 1997)
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{lacW}rho5
Cytology
Description

P{lacW} is inserted in or downstream of the rho promoter, at the 5' end of the rho transciption unit.

(Bier et al., 1990)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      chordotonal neuron

      (Bier et al., 1990)

      chordotonal organ | precursor & embryonic abdomen

      (Bier et al., 1990)

      embryonic epidermis

      (Bier et al., 1990)

      embryonic head & external sensory organ

      (Bier et al., 1990)

      embryonic thorax & external sensory organ

      (Bier et al., 1990)

      Keilin organ

      (Bier et al., 1990)

      larval antenno-maxillary sensory complex

      (Bier et al., 1990)

      larval VL3/4 motor neuron

      (Chiba et al., 1993)

      midline glial cell

      (Chiba et al., 1993)

      muscle cell of abdominal 1 ventral longitudinal muscle 4

      (Chiba et al., 1993)

      muscle cell of abdominal 1 ventral oblique muscle 1

      (Chiba et al., 1993)

      muscle cell of abdominal 1 ventral oblique muscle 2

      (Chiba et al., 1993)

      muscle cell of abdominal 2 dorsal acute muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 2 dorsal oblique muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 2 dorsal oblique muscle 4

      (Bier et al., 1990)

      muscle cell of abdominal 2 lateral longitudinal muscle 1

      (Bier et al., 1990)

      muscle cell of abdominal 2 ventral longitudinal muscle 4

      (Chiba et al., 1993)

      muscle cell of abdominal 2 ventral oblique muscle 1

      (Chiba et al., 1993)

      muscle cell of abdominal 2 ventral oblique muscle 2

      (Chiba et al., 1993)

      muscle cell of abdominal 3 dorsal acute muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 3 dorsal oblique muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 3 dorsal oblique muscle 4

      (Bier et al., 1990)

      muscle cell of abdominal 3 lateral longitudinal muscle 1

      (Bier et al., 1990)

      muscle cell of abdominal 3 ventral longitudinal muscle 4

      (Chiba et al., 1993)

      muscle cell of abdominal 3 ventral oblique muscle 1

      (Chiba et al., 1993)

      muscle cell of abdominal 3 ventral oblique muscle 2

      (Chiba et al., 1993)

      muscle cell of abdominal 4 dorsal acute muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 4 dorsal oblique muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 4 dorsal oblique muscle 4

      (Bier et al., 1990)

      muscle cell of abdominal 4 lateral longitudinal muscle 1

      (Bier et al., 1990)

      muscle cell of abdominal 4 ventral longitudinal muscle 4

      (Chiba et al., 1993)

      muscle cell of abdominal 4 ventral oblique muscle 1

      (Chiba et al., 1993)

      muscle cell of abdominal 4 ventral oblique muscle 2

      (Chiba et al., 1993)

      muscle cell of abdominal 5 dorsal acute muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 5 dorsal oblique muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 5 dorsal oblique muscle 4

      (Bier et al., 1990)

      muscle cell of abdominal 5 lateral longitudinal muscle 1

      (Bier et al., 1990)

      muscle cell of abdominal 5 ventral longitudinal muscle 4

      (Chiba et al., 1993)

      muscle cell of abdominal 5 ventral oblique muscle 1

      (Chiba et al., 1993)

      muscle cell of abdominal 5 ventral oblique muscle 2

      (Chiba et al., 1993)

      muscle cell of abdominal 6 dorsal acute muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 6 dorsal oblique muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 6 dorsal oblique muscle 4

      (Bier et al., 1990)

      muscle cell of abdominal 6 lateral longitudinal muscle 1

      (Bier et al., 1990)

      muscle cell of abdominal 6 ventral longitudinal muscle 4

      (Chiba et al., 1993)

      muscle cell of abdominal 6 ventral oblique muscle 1

      (Chiba et al., 1993)

      muscle cell of abdominal 6 ventral oblique muscle 2

      (Chiba et al., 1993)

      muscle cell of abdominal 7 dorsal acute muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 7 dorsal oblique muscle 3

      (Bier et al., 1990)

      muscle cell of abdominal 7 dorsal oblique muscle 4

      (Bier et al., 1990)

      muscle cell of abdominal 7 lateral longitudinal muscle 1

      (Bier et al., 1990)

      muscle cell of abdominal 7 ventral longitudinal muscle 4

      (Chiba et al., 1993)

      muscle cell of abdominal 7 ventral oblique muscle 1

      (Chiba et al., 1993)

      muscle cell of abdominal 7 ventral oblique muscle 2

      (Chiba et al., 1993)

      presumptive embryonic/larval peripheral nervous system

      (Bier et al., 1990)

      scolopidial dendritic cap cell

      (Bier et al., 1990)

      scolopidium

      (Bier et al., 1990)

      somatic muscle cell | dorsal

      (Chiba et al., 1993)
      Detailed Description
      Statement
      Reference

      Embryos have only three ventral longitudinal muscle fibres per abdominal hemisegment, instead of the usual 4: muscle 7 fails to develop. Development of other muscle fibres in the dorsal region and the ventral oblique muscle fibres 14.1 and 14.2 are abnormal. Embryos also lack several of the midline glia in the CNS. In the absence of muscle fibre 7 motoneuron RP3 innervates the remaining muscle fibre 6 in 83% of embryos, in the remaining 17% the growth cone fails to synapse with muscle 6 but project distally, they do not synapse before death at state 17. Deletion of muscle 7 does not affect RP1 growth cone behaviour.

      (Chiba et al., 1993)

      Similar to rho7M43 with respect to the PNS phenotype. Cuticular phenotype less severe than rho7M43 or rho6. CNS is apparently normal. Two of the five lateral chordotonal organs are missing. The chordotonal organ with the neuronal dendrite pointing ventrally can be missing from the ventral cluster. The es and md neurons in the abdominal segments are unaffected, though es organs in the head and thorax that are innervated by multiple neurons are reduced in number. Embryonic muscle pattern is abnormal. As well as the regular dorso-lateral muscle absences, ventral longitudinal muscles are also occasionally missing. Muscle attachment sites are sometimes relocated, with fibers attaching to the ventral midline.

      (Bier et al., 1990)

      weak allele embryonic lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      rho5/rho[+] is a suppressor of visible | heat sensitive phenotype of HC2.hs

      (Johannes and Preiss, 2002)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      rho5/rho[+] is a suppressor of wing vein | ectopic | heat sensitive phenotype of HC2.hs

      (Johannes and Preiss, 2002)

      rho5/rho[+] is a suppressor of wing | heat sensitive phenotype of HC2.hs

      (Johannes and Preiss, 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      rho7M43

      (Bier et al., 1990)
      Partially rescued by

      rho5 is partially rescued by rhoRyn

      (Bier et al., 1990)
      Comments

      rho5 is both partially rescued by two copies of rhoRyn : 40% of such embryos hatch as viable larvae, with rescued cuticular phenotype. Rescued larvae do not survive to adulthood.

      (Bier et al., 1990)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Bier.

      Comments
      Comments

      Can revert to wild type under dysgenic conditions.

      (Bier et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      rho5
      rho6-63a
      rholac1
      (zur Lage et al., 1997, Bier et al., 1990, Bier et al., 1990)
      rhomboidlac1
      (Chiba et al., 1993)
      ve5
      verho-lac1
      (Johannes and Preiss, 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)