FlyBase Allele Report: Dmel\vg[s2]

General Information

Symbol

Dmel\vg^s2

Species

D. melanogaster

Name

FlyBase ID

FBal0017906

Feature type

allele

Associated gene

Dmel\vg

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Abu-Issa and Cavicchi, 1993)

Mutagen

spontaneous

(Williams, 1956)

Progenitor genotype

Cytology

Description

5kb insertion in the distal part of the gene, between EcoRI site at +13kb and HindIII site at +15kb.

(Abu-Issa and Cavicchi, 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

insertion

2R:12,896,512..12,898,986 [+]

Linked to:

EcoRI-HindIII restriction fragment

Comment:

vg^s2 is associated with a 5kb insertion. The insertion site maps to the distal part of the gene.

(Abu-Issa and Cavicchi, 1993, Williams and Bell, 1988)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Abu-Issa and Cavicchi, 1996, Williams, 1956)

visible | recessive

(Abu-Issa and Cavicchi, 1993)

Phenotype Manifest In

wing

(Abu-Issa and Cavicchi, 1996, Williams, 1956)

wing sensillum | ectopic

(Abu-Issa and Cavicchi, 1993)

wing vein L2 & wing sensillum

(Abu-Issa and Cavicchi, 1996)

wing vein L3 & wing sensillum

(Abu-Issa and Cavicchi, 1996)

Detailed Description

Statement

Reference

Flies have terminal incisions in the wing, and have 3-4 ectopic bristles on veins L2 and L3.

(Abu-Issa and Cavicchi, 1996)

Homozygotes have slightly open wings that are turned down and distally notched. Wings show few trichomes in the triple, double and posterior rows, and etopic bristles on L3 and L4 veins. Transheterozygotes with many other vg alleles lead to the conclusion that this allele is a hypomorph. Like most vg alleles it complements vg^83b27.

(Abu-Issa and Cavicchi, 1993)

Wings are approximately one-fourth to one-half the normal width, varying to nearly full length. Wings are incised.

(Williams, 1956)

RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

N^55e11, vg^s2 has visible | dominant phenotype

(Abu-Issa and Cavicchi, 1996)

hry^unspecified, vg^s2 has visible | dominant phenotype

(Abu-Issa and Cavicchi, 1996)

N^55e11, vg^s2 has visible | recessive phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-3, vg^s2 has visible | dominant phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-3, vg^s2 has partially lethal phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-1, vg^s2 has visible | recessive phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-3, vg^s2 has visible | recessive phenotype

(Abu-Issa and Cavicchi, 1996)

hry^unspecified, vg^s2 has visible | recessive phenotype

(Abu-Issa and Cavicchi, 1996)

Phenotype Manifest In

Other

Statement

Reference

N^55e11, vg^s2 has wing phenotype

(Abu-Issa and Cavicchi, 1996)

hry^unspecified, vg^s2 has wing vein | ectopic phenotype

(Abu-Issa and Cavicchi, 1996)

hry^unspecified, vg^s2 has wing sensillum | ectopic phenotype

(Abu-Issa and Cavicchi, 1996)

hry^unspecified, vg^s2 has medial row of triple row of wing sensilla phenotype

(Abu-Issa and Cavicchi, 1996)

N^55e11, vg^s2 has wing sensillum | ectopic phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-1, vg^s2 has wing phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-3, vg^s2 has wing phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-3, vg^s2 has wing vein phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-3, vg^s2 has wing | ventral phenotype

(Abu-Issa and Cavicchi, 1996)

Additional Comments

Genetic Interactions

Statement

Reference

vg^s2/+ ; h^unspecified/h^unspecified flies show no notching of the wing but have more diffused ectopic bristles and ectopic veins. vg^s2/vg^s2; h^unspecified/h^unspecified double homozygotes have ectopic bristles almost covering the wing surface, ectopic veins are found all over the wing surface, and an additional row of stout bristles is seen parallel to those found in the proximal part of the wing. N^55e11/+ ; vg^s2/vg^s2 flies show increased cell death in the wing, and many ectopic bristles are found on the wing surface, especially on vein L4. N^nd-1/Y ; vg^s2/vg^s2 flies show notching of the wing. N^nd-3/Y ; vg^s2/+ flies lack the distal portion of the ventral wing blade. The wing is greatly reduced in N^nd-3/Y ; vg^s2/vg^s2 flies, and marginal structures and veins are missing. These double homozygotes have low viability.

(Abu-Issa and Cavicchi, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Williams, Mar. 1956

(Williams, 1956)

Comments

Excellent viability.

(Abu-Issa and Cavicchi, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

vg^s2

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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